Sökning: "conformational selection"

Visar resultat 1 - 5 av 18 avhandlingar innehållade orden conformational selection.

  1. 1. Computational Study of Calmodulin’s Ca2+-dependent Conformational Ensembles

    Författare :Annie M. Westerlund; Erik Lindahl; Lucie Delemotte; Björn Wallner; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular dynamics; Calmodulin; Free energy estimation; Gaussian mixture models; Spectral clustering; conformational selection; Biological Physics; Biologisk fysik;

    Sammanfattning : Ca2+ and calmodulin play important roles in many physiologically crucial pathways. The conformational landscape of calmodulin is intriguing. Conformational changes allow for binding target-proteins, while binding Ca2+ yields population shifts within the landscape. Thus, target-proteins become Ca2+-sensitive upon calmodulin binding. LÄS MER

  3. 2. The CD40 Receptor - Target,Tool and Technology

    Författare :Peter Ellmark; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; serology; transplantation; Immunologi; serologi; SPIRE; mammalian; library; cDNA; selection; receptor revision; phage display; scFv; human; CD40; antibodies;

    Sammanfattning : CD40 is a cell surface receptor of pivotal importance that is expressed on several of the cells in the immune system. It is critical for many important events, such as T cell dependent B cell activation, isotype switching, somatic mutation and generation of B cell memory. LÄS MER

  4. 3. Galectin-3 Ligand Binding: Mechanism and Driving Forces

    Författare :Olof Stenström; Biofysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Dynamics; NMR; ITC; Relaxation dispersion; NMR relaxation; Ligand binding; Thermodynamic; Galectin-3; Entropy; Binding Mechanism; Induced fit; Conformational selection;

    Sammanfattning : .... LÄS MER

  5. 4. Studies on the functional interaction of translation initiation factor IF1 with ribosomal RNA

    Författare :Jaroslav Belotserkovsky; Leif Isaksson; Diarmaid Hughes; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Escherichia coli; ribosome; rRNA mutation; molekylärgenetik; Molecular Genetics;

    Sammanfattning : Translation initiation factor IF1 is a small, essential and ubiquitous protein factor encoded by a single infA gene in bacteria. Although several important functions have been attributed to IF1, the precise reason for its indispensability is yet to be defined. LÄS MER

  7. 5. Small angle scattering as a tool to study protein structure and interactions

    Författare :Zuzanna Pietras; Maria Sunnerhagen; Eleonore von Castelmur; Cy Jeffries; Lars-Göran Mårtensson; Annette Langkilde; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : This thesis uses small angle X-ray and neutron scattering (SAXS/SANS) to gain structural and functional insight into the molecular regulation of critical life processes in prokaryotic and eukaryotic species. The presented studies highlight the strength of combining low-resolution structure determination with biophysical and in silico modelling methods to extensively characterize proteins and their interactions. LÄS MER