Sökning: "confirmatory trials"

Hittade 5 avhandlingar innehållade orden confirmatory trials.

  1. 1. Improved Methods for Pharmacometric Model-Based Decision-Making in Clinical Drug Development

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Anne-Gaëlle Dosne; Uppsala universitet.; [2016]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometrics; nonlinear mixed-effects models; confirmatory trials; residual error modeling; parameter uncertainty; sampling importance resampling; model-averaging; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Pharmacometric model-based analysis using nonlinear mixed-effects models (NLMEM) has to date mainly been applied to learning activities in drug development. However, such analyses can also serve as the primary analysis in confirmatory studies, which is expected to bring higher power than traditional analysis methods, among other advantages. LÄS MER

  2. 2. A contribution to the design and analysis of phase III clinical trials

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Vera Lisovskaja; Göteborgs universitet.; Gothenburg University.; [2013]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Clinical trials are an established methodology for evaluation of the effects of a new medical treatment. These trials are usually divided into several phases, namely phase I through IV. The earlier phases (I and II) are relatively small and have a more exploratory nature. LÄS MER

  3. 3. Confirmation Bias in Criminal Cases

    Detta är en avhandling från Uppsala : Department of Law, Uppsala University

    Författare :Moa Lidén; Uppsala universitet.; [2018]
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; legal decision making; bias; confirmation bias; criminal cases; criminal procedure; police; prosecutor; judge; legal system; empirical legal research; evidence based law; debiasing technique; Jurisprudence; Allmän rättslära;

    Sammanfattning : Confirmation bias is a tendency to selectively search for and emphasize information that is consistent with a preferred hypothesis, whereas opposing information is ignored or downgraded. This thesis examines the role of confirmation bias in criminal cases, primarily focusing on the Swedish legal setting. LÄS MER

  4. 4. Exposure and acceptance in patients with chronic debilitating pain : A behavior therapy model to improve functioning and quality of life

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Clinical Neuroscience

    Författare :Rikard K Wicksell; Karolinska Institutet.; Karolinska Institutet.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : A large number of patients suffer from reduced functioning and quality of life due to longstanding pain. The importance of psychological factors is undisputable and there is today substantial empirical support for treatments based on cognitive behavior therapy (CBT). Nevertheless, previous research also illustrates a clear need for improvements. LÄS MER

  5. 5. Evaluation of HIV testing strategies and monitoring of immune responses in HIV-vaccinated individuals in Tanzania

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Microbiology, Tumor and Cell Biology

    Författare :Said Aboud; Karolinska Institutet.; Karolinska Institutet.; [2011]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : This thesis describes studies on the evaluation of human immunodeficiency virus (HIV) enzyme-linked immunosorbent assays (ELISAs) and simple rapid HIV assays for use in HIV testing strategies in resource-limited settings and studies of HIV vaccine-induced immune responses. Peripheral blood mononuclear cell (PBMC) preparation techniques were also studied in preparation for use in the HIV vaccine trials. LÄS MER