Sökning: "confirmatory trials"
Visar resultat 1 - 5 av 9 avhandlingar innehållade orden confirmatory trials.
1. Improved Methods for Pharmacometric Model-Based Decision-Making in Clinical Drug Development
Sammanfattning : Pharmacometric model-based analysis using nonlinear mixed-effects models (NLMEM) has to date mainly been applied to learning activities in drug development. However, such analyses can also serve as the primary analysis in confirmatory studies, which is expected to bring higher power than traditional analysis methods, among other advantages. LÄS MER
2. A contribution to the design and analysis of phase III clinical trials
Sammanfattning : Clinical trials are an established methodology for evaluation of the effects of a new medical treatment. These trials are usually divided into several phases, namely phase I through IV. The earlier phases (I and II) are relatively small and have a more exploratory nature. LÄS MER
3. Confirmation Bias in Criminal Cases
Sammanfattning : Confirmation bias is a tendency to selectively search for and emphasize information that is consistent with a preferred hypothesis, whereas opposing information is ignored or downgraded. This thesis examines the role of confirmation bias in criminal cases, primarily focusing on the Swedish legal setting. LÄS MER
4. Socioeconomic status and myocardial infarction : influence on secondary prevention and prognosis
Sammanfattning : Background and Aims: In the wealth of research undertaken on myocardial infarctions (MIs), secondary prevention is less well studied. Incidence and death from MI have declined substantially in the past decades due to the identification of cardiovascular (CV) risk factors, methods to assess risk in the general population, development of efficient therapies that modify risk factor levels, and the introduction of revascularization therapies used in the acute phase of a MI. LÄS MER
5. Exposure and acceptance in patients with chronic debilitating pain : a behavior therapy model to improve functioning and quality of life
Sammanfattning : A large number of patients suffer from reduced functioning and quality of life due to longstanding pain. The importance of psychological factors is undisputable and there is today substantial empirical support for treatments based on cognitive behavior therapy (CBT). Nevertheless, previous research also illustrates a clear need for improvements. LÄS MER