Sökning: "complex diseases"
Visar resultat 1 - 5 av 796 avhandlingar innehållade orden complex diseases.
1. Immune Complex Regulated Cytokine Production in Rheumatic and Lymphoproliferative Diseases
Sammanfattning : Immune complexes (ICs) are produced during normal immune responses and facilitate clearance of foreign antigens. ICs not efficiently cleared from the circulation can cause tissue damage. This might happen if ICs are formed with autoantibodies and autoantigens. LÄS MER
2. Strategies for Identification of Susceptibility Genes in Complex Autoimmune Diseases
Sammanfattning : Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are complex autoimmune diseases affecting 0.05-2% of the population worldwide. Genetic studies detected linkage with SLE in the 2q37 region, and intensive family-based and case-control association studies in several populations identified that allele A of the SNP PD-1. LÄS MER
3. Patterns in big data bioinformatics : Understanding complex diseases with interpretable machine learning
Sammanfattning : Alterations in the flow of genetic information may lead to complex diseases. Such changes are measured with various omics techniques that usually produce the so-called “big data”. Using interpretable machine learning (ML), we retrieved patterns from transcriptomics data sets. LÄS MER
4. Uncovering biomarkers and molecular heterogeneity of complex diseases : Utilizing the power of Data Science
Sammanfattning : Uncovering causal drivers of complex diseases is yet a difficult challenge. Unlike single-gene disorders complex diseases are heterogeneous and are caused by a combination of genetic, environmental, and lifestyle factors which complicates the identification of patient subgroups and the disease causal drivers. LÄS MER
5. Elucidation of complex diseases by machine learning
Sammanfattning : Uncovering the interpretability of models for complex health-related problems is a crucial task that is often neglected in machine learning (ML). The amount of available data makes the problem even more complicated. LÄS MER