Sökning: "competitive inhibitors"
Visar resultat 1 - 5 av 45 avhandlingar innehållade orden competitive inhibitors.
1. Homotrimeric dUTPases : Principles of Catalysis and Inhibitor Design
Sammanfattning : The ubiquitous enzyme dUTPase hydrolyzes dUTP into dUMP and pyrophosphate, preventing DNA fragmentation and cell death due to accumulation of dUTP. Inhibitors of dUTPase could serve as drugs in the treatment of cancers and infectious diseases. This thesis presents five studies. LÄS MER
2. Computational Modelling of Structures and Ligands of CYP2C9
Sammanfattning : CYP2C9 is one of our major drug metabolising enzymes and belongs to the cytochrome P450 (CYP) super family. The aim of this thesis was to gain an understanding of the quantitative structure–activity relationships (QSAR) of CYP2C9 substrates and inhibitors. LÄS MER
3. Design, synthesis and evaluation of bacterial sialic acid uptake inhibitors
Sammanfattning : Antibiotic resistance is a major threat for our society and finding novel antibacterial therapies is of greatimportance. In this thesis, we investigate bacterial sialic acid uptake inhibitors as a novel antibacterial approach.Bacteria do not biosynthesise sialic acid and therefore harvest it from the host. LÄS MER
4. Knowledge Dissemination in Multinational Corporations
Sammanfattning : Today’s globalization trend in industry is of major importance for world economy. One effect of the globalization trend is that international companies are exposed to a broadened knowledge base. A major competitive advantage for a multinational corporation (MNC) is its ability to utilize knowledge that is situated at the different locations. LÄS MER
5. CRISPRi/a for investigating yeast tolerance to inhibitors in lignocellulosic hydrolysates
Sammanfattning : Saccharomyces cerevisiae has immense potential as a cell factory in various biotechnological processes where biomass from agricultural industry residues is used as feedstock. Nonetheless, the inhibitors released during the pretreatment of the biomass makes lignocellulosic hydrolysates a challenging substrate for microorganisms. LÄS MER