Sökning: "compensatory mutations"
Visar resultat 1 - 5 av 28 avhandlingar innehållade orden compensatory mutations.
1. Mechanisms of Adaptation to Deformylase Inhibitors
Sammanfattning : Antibiotic resistance is a growing problem on a global scale. Increasing numbers of bacteria resistant toward one or multiple antibiotics could return us to the high mortality rates for infectious diseases of the pre-antibiotic era. LÄS MER
2. DNA precursor asymmetries, Mismatch Repair and their effect on mutation specificity
Sammanfattning : In order to build any structure, a good supply of materials, accurate workers and quality control are needed. This is even the case when constructing DNA, the so-called “Code of Life.” For a species to continue to exist, this DNA code must be copied with incredibly high accuracy when each and every cell replicates. LÄS MER
3. Surviving the ratchet : Modelling deleterious mutations in asexual populations
Sammanfattning : One of the most unforgiving processes in nature is that of Muller's ratchet, a seemingly irreversible accumulation of deleterious mutations that all organisms have to deal with or face extinction. The most obvious way to avoid fitness collapse is recombination, though asexual populations usually do not have the luxury of recombining freely. LÄS MER
4. Mechanisms of adaptive mutations in bacteria
Sammanfattning : Bacteria have the ability to adapt to various challenging environments. The rate, extent and consequences of bacterial adaptation depend on both microbial and environmental factors. LÄS MER
5. Spread and distribution of drug resistance and compensatory mutations in Plasmodium falciparum
Sammanfattning : In 2010 there were an estimated 216 million cases of malaria worldwide. In Honduras there were ~9000 cases of which 88% were due to Plasmodium vivax mono-infection. Chloroquine (CQ) resistant Plasmodium falciparum have spread throughout the world curtailing its use. LÄS MER
