Sökning: "combination therapies"

Visar resultat 6 - 10 av 173 avhandlingar innehållade orden combination therapies.

1. 6. Regulation of DNA damage responses by the Myc oncogene : implications for future anti-cancer therapies

   Författare :Andreas Höglund; Jonas Nilsson; Thomas Helleday; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Myc; DNA damage; Decitabine; Chk1; Chk2; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

   Sammanfattning : Myc is a transcription factor frequently found deregulated in human cancer. Cells with deregulated expression of Myc carry a selective advantage against its neighbours due to the fact that Myc-mediated transcription governs crucial cellular events such as proliferation and growth. LÄS MER

3. 7. Pharmacometrics for Combination Therapy in Oncology Within and Across Species Variability in Time Series and Time-to-event Data

   Författare :Marcus Baaz; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mathematical Modeling; Pharmacometrics; Nonlinear Mixed Effects; Oncology; Combination Therapy; Radiation Therapy;

   Sammanfattning : Mathematical modeling is an integral part of the drug development process. Models are developed to describe tumor dynamics or drug concentration to answer questions such as: What concentration is required to reach the desirable treatment outcome? What drug dose and frequency should a drug prescription specify to achieve this concentration? Models are also used for simulation, reducing the need to perform additional animal trials. LÄS MER

4. 8. Pharmacokinetics and Pharmacodynamics of Anti-Cancer Regimens : Emphasis on Busulphan and the Combination Therapies Epirubicin-Docetaxel and Fluorouracil-Epirubicin-Cyclophosphamide

   Författare :Marie Sandström; Alison H Thomson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Pharmacognosy; farmakognosi;

   Sammanfattning : Although the main reason for the lack of distinct dose-response and -toxicity relationships for anti-cancer agents is due to variability in pharmacodynamics, variability in pharmacokinetics may also contribute. Hence, not only describing and quantifying the relationship between pharmacokinetics and dose-limiting toxicities, but characterising the pharmacokinetics and its associated variability are of obvious importance in the process of developing dosing strategies for anti-cancer regimens. LÄS MER

5. 9. Experimental pharmacodynamic and kinetic studies related to new combination therapies against P. falciparum malaria

   Författare :Seema Gupta; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Artemisinin (ART) class of compounds are of special interest due to their rapid onset of action and high activity against multidrug resistant malaria. The major drawback in monotherapy with ART and its derivatives is the high rate of recrudescent infection. LÄS MER

7. 10. Preclinical investigation of novel therapies against neuroblastoma

   Författare :Karin Hansson; Avdelningen för translationell cancerforskning; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Neuroblastoma; Translational research; Preclinical drug evaluation;

   Sammanfattning : Neuroblastoma is a childhood tumor of the sympathetic nervous system and the most common tumor form diagnosed in infants. Patients with aggressive tumors are treated intensely with multi-modal therapy including chemotherapy, surgery, radiotherapy and immunotherapy. LÄS MER