Sökning: "colorectal metastasis"

Visar resultat 1 - 5 av 48 avhandlingar innehållade orden colorectal metastasis.

1. 1. Colorectal Liver Metastases : Onco-surgical Strategies & Prognostic Factors

   Författare :Petter Frühling; Bengt Isaksson; Ville Sallinen; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colorectal cancer; liver metastases; chemotherapy; oncological treatment; prognostic factors; predictive model; simultaneous resection; liver-first; colorectal-first;

   Sammanfattning : The management of patients with colorectal cancer with liver metastases has improved over the past decades. There have been significant developments in terms of surgery, local therapies, anesthesia and oncological treatment. Nevertheless, there is no consensus on what constitutes optimal treatment strategy. LÄS MER

3. 2. Prognostic and predictive factors in colorectal cancer

   Författare :Kristoffer Derwinger; Göteborgs universitet; []
   Nyckelord :colorectal cancer; prognosis; lymph nodes; lymph node ratio; MTHFR; cyclin E; TNM; staging; metastasis;

   Sammanfattning : Aim: The aim of the thesis was to study prognostic and predictive factors in patients treated for colorectal cancer (CRC). Method: In paper I, a retrospective comparison was made between the patients treated in 1999 (n=180) with those treated in 2004 (n=175). LÄS MER

4. 3. Estrogen receptors and inflammation in colorectal cancer. Role in prognosis and therapeutic opportunities

   Författare :Geriolda Topi; Malmö Cellpatologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colorectal Cancer; Estrogen Receptor alpha; Estrogen receptor beta; Prognosis and survival; Zebrafish; Metastasis; ERB-041; PPT; AZD9496; Mast cells; Cysteinyl leukotriene receptors;

   Sammanfattning : .... LÄS MER

5. 4. From Tissue to Mutations : Genetic Profiling of Colorectal Cancer

   Författare :Lucy Mathot; Tobias Sjöblom; Mats Nilsson; Alberto Bardelli; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Nucleic acid extraction; genotyping; targeted sequencing; mutation analysis; colorectal cancer; metastatic disease; Medical Science; Medicinsk vetenskap;

   Sammanfattning : Comprehensive characterisation of the mutational landscapes of solid tumours is a multistep process involving the collection of suitable samples, the extraction of nucleic acids and the preparation of these materials for mutational analyses. In this thesis, I aimed to develop a streamlined process for the analysis of colorectal cancer (CRC) patient samples in order to identify novel mutations that hallmark the development of advanced disease. LÄS MER

7. 5. Colorectal cancer and radiation response : The role of EGFR, AKT and cancer stem cell markers

   Författare :Sara Häggblad Sahlberg; Bo Stenerlöw; Bengt Glimelius; Marika Nestor; Torgny Stigbrand; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; colorectal cancer; radiation; AKT; EGFR; cancer stem cells; CD133; CD44; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap; Biologi med inriktning mot molekylär cellbiologi; Biology with specialization in Molecular Cell Biology;

   Sammanfattning : The primary treatment for colorectal cancer is surgery. Radiotherapy and chemotherapy, sometimes combined, are also frequently used to diminish recurrence risk. In response to radiation exposure, several cellular signaling cascades are activated to repair DNA breaks, prevent apoptosis and to keep the cells proliferating. LÄS MER