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Visar resultat 1 - 5 av 16 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Microcirculation, Mucus and Microbiota in Inflammatory Bowel Disease

   Författare :Olof Schreiber; Lena Holm; Mia Phillipson; Henrik Sjövall; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; inflammatory bowel diseases; experimental colitis; DSS; TNBS; colonic mucosal blood flow; laser-doppler flowmetry; colonic mucus thickness; MUC2; colonic mucosal barrier function; iNOS; eNOS; probiotics; Lactobacilli; Lactobacillus reuteri; colonic microbiota; T-RFLP; bacterial translocation; intravital microscopy; P-selectin; leukocyte recruitment; platelet recruitment; Physiology; Fysiologi; Physiology; Fysiologi;

   Sammanfattning : Inflammatory bowel diseases, (IBD), are a group of chronic disorders of the gastro-intestinal tract, and include Crohn’s disease (CD) and Ulcerative Colitis (UC). The pathogenesis is not known, but involves at least in part a loss of tolerance towards the commensal colonic microbiota. LÄS MER

3. 2. Neuro-immuno-regulation of inflammation in the colonic mucosa : Focus on mast cells and eosinophils in bowel disorders

   Författare :Maria Teresa Casado Bedmar; Åsa Keita; Johan D Söderholm; Marie Carlson; Melanie Gareau; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mast cells; Eosinophils; Vasoactive intestinal polypeptide; Neuro-immune; Intestinal barrier; Irritable bowel syndrome; Inflammatory bowel diseases; Ussing chamber; Advance image analysis;

   Sammanfattning : Intestinal homeostasis is key to control uptake across the mucosa and protect from harmful substances. Disturbances in the bidirectional communication between the gut and the brain are implicated in irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD), being Crohn’s disease (CD) and ulcerative colitis (UC) the two most common IBD subtypes. LÄS MER

4. 3. Collagenous colitis : The influence of inflammation and bile acids on intestinal barrier function

   Författare :Andreas Münch; Magnus Ström; Johan Söderholm; Magnus Simrén; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : Background and aims: Collagenous colitis (CC) is a diarrheal disorder with an incidence rate of 5-6/100000 inhabitants, affecting mainly middle-aged women. The diagnosis is made by histology of the colonic mucosa. Classical findings are a thickened subepithelial collagenous layer and chronic inflammation in the lamina propria. LÄS MER

5. 4. Studies of barrier function in patients with ulcerative colitis and pouchitis

   Författare :Mats Persborn; Johan Söderholm; Lars Börjesson; Maria Jenmalm; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : Background and aim: The cause of ulcerative colitis (UC) is largely unknown. However, there is a presumed genetic component to susceptibility and altered intestinal barrier function has been implicated in the pathophysiology of ulcerative colitis. LÄS MER

7. 5. Role of Melatonin, Neuropeptide S and Short Chain Fatty Acids in Regulation of Duodenal Mucosal Barrier Function and Motility

   Författare :Wan Salman Wan Saudi; Markus Sjöblom; Olof Nylander; Mark Berner-Hansen; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 51Cr-EDTA; rat; in vivo; duodenum; enteric nervous system; paralytic ileus; parecoxib; bicarbonate secretion; motility; ethanol; HCl; melatonin; neuropeptide S; short chain fatty acids; chemosensing; Physiology; Fysiologi;

   Sammanfattning : The duodenal epithelium is regularly exposed to HCl, digestive enzymes, bacteria and toxins, and sometimes also to ethanol and drugs. The imbalance of aggressive factors in the intestinal lumen and mucosal barrier function increases the risk of tissue injury and inflammation. LÄS MER