Sökning: "colon msi"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden colon msi.

1. 1. Associations of sex, anthropometric and reproductive factors with clinicopathological and molecular characteristics of colorectal cancer

   Författare :Jenny Brändstedt; Tumörmikromiljö; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colorectal cancer; carcinogenesis; MDCS; anthropometrics; risk factors; sex differences; hormonal therapy; beta-catenin; cyclin D1; p53; MSI; KRAS mutation; BRAF mutation;

   Sammanfattning : Colorectal cancer (CRC) is the third most common cancer globally, with approximately 1.2 million new cases every year. The highest incidence rates are seen in developed countries, thereby imposing dietary and lifestyle factors in the etiology of CRC. LÄS MER

3. 2. Cancer of the Colon and Rectum : Prognostic Factors and Early Detection

   Författare :Ulrik Wallin; Helgi Birgisson; Niels Qvist; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colorectal cancer screening predictive markers prognostic markers;

   Sammanfattning : Colorectal cancer (CRC) is one of the most common causes of death from malignant disease. Nevertheless, no ideal screening method exists and there is a lack of prognostic and predictive factors to support clinical decisions and to aid the development of a more individualized treatment for patients with CRC. LÄS MER

4. 3. Hereditary Nonpolyposis Colorectal Cancer - Molecular Genetics and Biology of Associated Tumors

   Författare :Maria Planck; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; endometrial cancer; rectal cancer; colon cancer; mismatch repair protein expression; coding repeats; microsatellite instability; MSH6; MSH2; Hereditary nonpolyposis colorectal cancer; MLH1; small bowel cancer; Cytology; oncology; cancerology; Cytologi; onkologi; cancer;

   Sammanfattning : This thesis focuses on one of the most common types of hereditary cancer, hereditary nonpolyposis colorectal cancer (HNPCC). This syndrome is characterized by an autosomal dominant inheritance, an increased risk for several types of cancer (especially cancer of the colorectum, small bowel, endometrium, ovary and urinary tract), early age at diagnosis, and frequent development of multiple primary malignancies. LÄS MER

5. 4. The CpG island methylator phenotype in colorectal cancer : studies on risk and prognosis

   Författare :Anna Dahlin; Richard Palmqvist; Bethany van Guelpen; Maria Henriksson; Åke Öberg; Xiao-Feng Sun; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colorectal cancer; DNA methylation; folate; microsatellite instability MSI ; prognosis; risk factors; t-lymphocytes; the CpG island methylator phenotype CIMP ; Vitamin B12; Pathology; Patologi; Tumour biology; Tumörbiologi; patologi; Pathology;

   Sammanfattning : Background Colorectal cancer (CRC) is the second most common malignancy in developed countries. The mortality is high, with nearly half of patients dying from the disease. The primary treatment of CRC is surgery, and decisions about additional treatment with chemotherapy are based mainly on tumor stage. LÄS MER

7. 5. Different genetic pathways involved in colorectal cancer

   Författare :Sima Salahshor; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Colorectal cancer (CRC) is one of the three leading causes of cancer mortality worldwide with an incidence of approximately one million cases and a mortality of 500 000 annually. Identification of different pathways involved in tumorigenesis of both familial and sporadic colorectal cancer may led to a major breakthrough in the prevention of this potentially curable disease. LÄS MER