Sökning: "collateral toxicity"

Hittade 3 avhandlingar innehållade orden collateral toxicity.

  1. 1. Deciphering molecular mechanisms in the evolution of new functions

    Författare :Hind Abdalaal; Joakim Näsvall; Paul Rainey; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Evolvability; functional trade-offs; collateral toxicity; duplication and amplification; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology; Biologi med inriktning mot molekylär evolution; Biology with specialization in Molecular Evolution;

    Sammanfattning : The evolution of new genes and functions is considered to be a major contributor to biological diversity in organisms. Through de novo origination, “duplication and divergence”, and horizontal gene transfer, organisms can acquire new genetic material that can evolve to perform novel functions. LÄS MER

  3. 2. Evolutionary Mechanisms Shaping Bacterial Translation Termination

    Författare :Shreya Pundir; Suparna Sanyal; Martin Ott; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Ribosome; Protein; Release Factor; Translation; Termination; Stop codon; Evolution; Mutation; Kinetics; Cryo-EM; Molekylär biovetenskap; Molecular Life Sciences;

    Sammanfattning : Translation termination in bacteria involves precise reading of stop codons (UAA, UAG, UGA) and coordinated peptidyl-tRNA hydrolysis by the class-I release factors (RFs) on the ribosome (70S). This thesis investigates the evolutionary and post-translational modification mechanisms of these RFs and the concurrent effect on bacterial translation termination. LÄS MER

  4. 3. Strategies of gene and immune therapy for tumors and viral diseases

    Författare :Herman José Arteaga; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Intracellular cytokines; DNA vaccine-GM-CSF; HIV- 1; RNA interference;

    Sammanfattning : In the treatment of tumors and viral diseases such as HIV-1 infection, immunotherapeutic strategies do not seem to have enough capacity to eradicate an already established disease. However, these strategies could play a unique role as adjuvant treatments of therapies that eliminate the main tumor or viral load in order to avoid the relapse of the disease. LÄS MER