Sökning: "collagen"

Visar resultat 21 - 25 av 519 avhandlingar innehållade ordet collagen.

1. 21. Cartilage proteins and their arthritogenic properties in arthritis

   Författare :Stefan Carlsén; Immunologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Immunologi; serologi; serology; Immunology; HLA-DR4; tolerance; COMP; CXI; CIX; arthritis; Cartilage; collagen;

   Sammanfattning : In this thesis the role of cartilage proteins and their potential as antigen and availability to the immune system in arthritis were investigated. Six papers are included; where four present new animal models for Rheumatoid arthritis (RA), one shows how genetic disorders in cartilage may affect arthritis and the last how posttranslational modification of collagen type II (CII) affects tolerance. LÄS MER

3. 22. Synchrotron-based characterization of mechanobiological effects on the nanoscale in musculoskeletal tissues

   Författare :Isabella Silva Barreto; Avdelningen för Biomedicinsk teknik; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; nanoscale; microscale; mechanical properties; synchrotron; x-ray imaging; collagen; hydroxyapatite; biomechanics; experimental mechanics; x-ray tomography; small-angle x-ray scattering SAXS ; wide-angle x-ray scattering WAXS ; x-ray fluorescence XRF ; small-angle x-ray scattering tensor tomography SASTT ; Fourier-transform infrared spectroscopy FTIR ; polarized light microscopy PLM ; bone development; Achilles tendon; tendon healing;

   Sammanfattning : Collagen is the main organic building block of musculoskeletal tissues. Despite collagen being their smallest load bearing unit, these tissues differ significantly in mechanical function and properties. A major factor behind these differences is their hierarchical organization, from the collagen molecule up to the organ scale. LÄS MER

4. 23. Biomolecular Aspects of Flexor Tendon Healing

   Författare :Maria Berglund; Monica Wiig; Olof Nilsson; Jan Fridén; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Flexor tendon healing; Growth factor; Metalloproteinase; Collagen; Proteoglycan; Myofibroblast; Hyaluronan synthase; Mast cell; Hand surgery; Handkirurgi; Orthopaedics; Ortopedi;

   Sammanfattning : Flexor tendon injuries in zone II of the hand (i.e. between the distal volar crease and the distal interphalangeal joint) can be costly for both the afflicted individual and society because of the high cost of a long rehabilitation period, complicated by tendon ruptures or scarring with adhesion formation, causing impaired range of motion. LÄS MER

5. 24. Proteins of the Inter-α-inhibitor Family : Biosynthesis, Plasma Clearance and Interaction with Extracellular Matrix Components

   Författare :Aneta Kaczmarczyk; Erik Fries; Anders Malmström; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; bikunin; inter-α-inhibitor; pre-α-inhibitor; intracellular processing; plasma clearance; extracellular matrix; binding; collagen; Biokemi; Biochemistry; Biokemi; Medical Biochemistry; medicinsk biokemi;

   Sammanfattning : Bikunin, a chondroitin sulfate-containing protein of 25 kDa, has protease inhibitory activity and occurs in the plasma in free and complexed form. In inter-α-inhibitor (IαI) and pre-a-inhibitor (PαI) it is covalently linked through its chondroitin sulfate (CS) chain to two or one other polypeptide of about 80 kDa – heavy chains 1 and 2 (H1, H2) and heavy chain 3 (H3) – respectively. LÄS MER

7. 25. Regulation of aortic wall mechanics and stress : An experimental study in man

   Författare :Håkan Åstrand; Toste Länne; Matts Karlsson; Martin Björck; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Aorta; wall stress; remodeling; IMT; gender; diabetes mellitus; aging; collagen; elastin; Vascular surgery; Kärlkirurgi;

   Sammanfattning : The abdominal aorta (AA) in man is a vulnerable artery prone to atherosclerosis as well as aneurysmatic dilation. The underlying aortic composition, mechanical properties as well as the mechanisms responsible for age-related changes and vascular disease are however largely unknown. LÄS MER