Sökning: "colchicine"

Visar resultat 1 - 5 av 13 avhandlingar innehållade ordet colchicine.

  1. 1. Tracing History : Phylogenetic, Taxonomic, and Biogeographic Research in the Colchicum Family

    Författare :Annika Vinnersten; Kåre Bremer; Bertil Nordenstam; Jerrold I Davis; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biology; biogeography; Colchicaceae; colchicine; dating; phylogeny; taxonomy; Biologi; Biology; Biologi;

    Sammanfattning : This thesis concerns the history and the intrafamilial delimitations of the plant family Colchicaceae. A phylogeny of 73 taxa representing all genera of Colchicaceae, except the monotypic Kuntheria, is presented. LÄS MER

  3. 2. Approaches to Pharmacological Treatment and Gene Therapy of Cystic Fibrosis

    Författare :Anca Dragomir; Godfried M. Roomans; Robert Dormer; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anatomy; airway epithelium; colchicine; cystic fibrosis; chloride transport; genotype; heparin; phenotype; transfection; X-ray microanalysis; Anatomi; Anatomy; Anatomi;

    Sammanfattning : Cystic fibrosis (CF) is the most common lethal genetic disease in the white population. It is due to mutations in the gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR), a protein that functions mainly as a cAMP-activated chloride channel. LÄS MER

  4. 3. Structure-activity studies of novel colchicine analogs

    Författare :Håkan Bladh; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Organisk kemi;

    Sammanfattning : Colchicine, a well-known alkaloid isolated from Colchicum autumnale, interferes with microtubule growth and, therefore affects mitosis and other microtubule dependent functions. We have been interested in the structural requirements of colchicine for tubulin recognition. LÄS MER

  5. 4. Nitric oxide in brain contusion

    Författare :Caroline Gahm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Apoptosis; Colchicine; Dexamethasone; eNOS; human; immunohistochemistry; iNOS; L-NAME; L-NIL; neuronal degeneration; Nimodipine; nitric oxide; NO; nNOS; rat; SPBN; Tirilazad Mesylate; traumatic brain injury;

    Sammanfattning : Trauma to the brain is a leading cause of death and disability. The primary injury initiates a cascade of biochemical reactions in the brain that causes further neuronal damage, a process referred to as secondary brain injury. LÄS MER

  7. 5. Neuronal apoptosis in excitotoxicity : involvement of nitric oxide and cytoskeletal damage

    Författare :Emanuela Bonfoco; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In the nervous system apoptosis may play an important role in the development of several neurodegenerative diseases. The overall objective of the present work is to investigate at the cellular and molecular levels, the mechanisms by which neurons are signaled to undergo apoptotic cell death after exposure to various effectors, such as nitric oxide (NO) and its byproducts, glutamate, and colchicine. LÄS MER