Sökning: "co-stimulatory molecules"

Visar resultat 1 - 5 av 32 avhandlingar innehållade orden co-stimulatory molecules.

1. 1. Co-stimulatory molecules : genes to protein in autoimmune and inflammatory disorders

   Författare :Priya Sakthivel; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Co‐stimulatory molecules are antigen‐independent generators of secondary signals which aid in maintaining the homeostasis of the immune system. The most extensively studied co‐stimulatory pathway is CD28/CTLA‐4, expressed on the T cells, interacting with CD80/CD86, expressed on the antigen presenting cells (APC). LÄS MER

3. 2. Studies on co-stimulatory molecules, chemokines and chemokine receptors in neuroimmunological diseases

   Författare :Natalia Teleshova; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Background: Multiple sclerosis (MS) and myasthenia gravis (MG) are characterised by activation of T cells directed against self antigens. Such autoreactive T cells are considered to play a central role in destruction of myelin in MS and in damage of neuromuscular junctions in MG. LÄS MER

4. 3. Immunopathology and signalling molecules involved during experimental African trypanosomiasis

   Författare :Ragaa Abdelkhalig Eltayeb; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :African Trypanosomiasis; Cytokines; Chemokines; Co-stimulatory molecules; Immunopathogenesis; T.b. brucei;

   Sammanfattning : In humans, African trypanosomiasis occurs in two forms; the chronic West African form is caused by T.b. gambiense and the acute or subacute East African form is caused by T.b. LÄS MER

5. 4. Immunological properties of dendritic cells in HIV-1 infection

   Författare :Karin Loré; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Dendritic cells; HIV-1; Cytokines; Chemokines; Co-stimulatory molecules; Apoptotic bodies; Lymphoid tissue;

   Sammanfattning : Dendritic cells (DCs) capture antigens for intracellular processing to form MHC-peptide complexes involved in the generation of antigen specific T cell responses. After encountering microbes, DCs migrate from the periphery to the regional lymph nodes. LÄS MER

7. 5. Characterisation of the interaction between the Hepatitis B virus core antigen and B cells

   Författare :Una Lazdina; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :HBcAg; B cells; B cell antigen receptor; co-stimulatory molecules; cytokines; T helper cells; cytotoxic T cells;

   Sammanfattning : The Hepatitis B virus (HBV) is a major cause of severe human liver disease globally. There are around 350 million persistent HBV carriers with a risk of development of liver disease including cirrhosis and hepatocellular carcinoma. LÄS MER