Sökning: "co-localisation"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet co-localisation.

1. 1. Cellular Uptake of Cystatin C. Subcellular localisation and intracellular effects of a secreted cysteine protease inhibitor

   Författare :Hanna Wallin; Avdelningen för klinisk kemi och farmakologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cathepsin; cell line; co-localisation; cystatin C; internalisation; legumain;

   Sammanfattning : Cystatin C is a cysteine protease inhibitor, aimed for secretion, as it is produced with a signal peptide. Its target enzymes are thought to be the lysosomal cysteine cathepsins and legumain. LÄS MER

3. 2. Short-chain retinol dehydrogenases/reductases : Involvement in retinoid metabolism and expression in embryonic and adult mouse

   Författare :Paulina Tuvendal; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; -; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Toxicology; toxikologi;

   Sammanfattning : Retinoids are needed in the embryo to ensure proper development and in the adult forvision, maintenance of epithelia and sperm production. Retinol is oxidised within the cell generating retinal and, irreversibly, retinoic acid. LÄS MER

4. 3. Evolution of Vertebrate Vision by Means of Whole Genome Duplications : Zebrafish as a Model for Gene Specialisation

   Författare :David Lagman; Dan Larhammar; Xesús M Abalo; Finn Hallböök; Stephan Neuhauss; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; phylogenetics; evolution; vision; visual opsin; transducin; PDE6; genome duplications; subfunctionalisation; Medicinsk vetenskap; Medical Science;

   Sammanfattning : The signalling cascade of rods and cones use different but related protein components. Rods and cones, emerged in the common ancestor of vertebrates around 500 million years ago around when two whole genome duplications took place, named 1R and 2R. LÄS MER

5. 4. New neurons and astrocytes in the adult brain. Studies on adult rat neural progenitors in vivo and in vitro with special reference to the effects of IGF-I and CNTF regarding proliferation and lineage determination

   Författare :Maria A I Åberg; Göteborgs universitet; []
   Nyckelord :Brain; hippocampus; rat; neurogenesis; progenitor cell; stem cell; ciliary neurotrophic factor; insulin-like growth factor-I; PI3-K; MAPK.;

   Sammanfattning : The hippocampal dentate gyrus in several species, including man, continues to produce new neurons and glial cells in adulthood. The generation of new neurons and glial cells in the adult hippocampus is under strict regulation. Two major events of significance for cell genesis from progenitor cells are proliferation and lineage determination. LÄS MER

7. 5. Molecular analysis of protein complexes involved in pairing of mammalian chromosomes during meiosis

   Författare :Jeanette Pelttari Danielsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : How is the accuracy of chromosomal pairing and segregation processes in dividing meiotic cells assured? This is an important question as premature or erratic segregation of chromosomes can give rise to aneuploidy, which is the leading genetic cause of pregnancy loss in humans. Meiosis is a cell division process that produces genetically unique haploid gametes from diploid cells. LÄS MER