Sökning: "co-expression network"
Visar resultat 1 - 5 av 19 avhandlingar innehållade orden co-expression network.
1. A genomic approach to smooth muscle differentiation and diversity
Sammanfattning : Smooth muscle cells (SMCs) are a broad class of contractile cells that are found in a number of organs systems, including the vasculature, the urogenital system, the bronchi and the gastrointestinal tract. The two main functions exerted by SMCs are to provide contractile force and to synthesize structural components of the extracellular matrix. LÄS MER
2. Data integration for robust network-based disease gene prediction
Sammanfattning : For many complex diseases the cause/mechanism can be tied not to a single gene and in order to cope with the complexity a systems wide approach is needed. By combining evidence indicative of functional association it is possible to infer networks of protein functional coupling. LÄS MER
3. Omics Data Analysis of Complex Diseases and Traits
Sammanfattning : Following the advent of the high-throughput techniques for producing massive omics data, new possibilities and challenges have also emerged in different fields of biology and medicine. Dealing with such data on different scales with different scopes such as genomics, transcriptomics, proteomics and metabolomics, demands appropriate data collection, preprocessing, statistical analysis, interpretation and visualization. LÄS MER
4. Adaptation in two species of Phaseolus with contrasting mating systems
Sammanfattning : For common bean, the loss of photoperiod sensitivity has been a major pre-requisite for domestication and further adaptation to European climates. Its self-pollinated mating system also makes it a good model for identifying genes that display enhanced levels of differentiation in gene expression, together with its closely related species, open-pollinated runner bean. LÄS MER
5. Multimodal and multiscale brain networks : understanding aging, Alzheimer’s disease, and other neurodegenerative disorders
Sammanfattning : The human brain can be modeled as a complex network, often referred to as the connectome, where structural and functional connections govern its organization. Several neuroimaging studies have focused on understanding the architecture of healthy brain networks and have shed light on how these networks evolve with age and in the presence of neurodegenerative disorders. LÄS MER