Sökning: "clonal complex"

Visar resultat 1 - 5 av 41 avhandlingar innehållade orden clonal complex.

  1. 1. Invasive Pneumococcal Infections

    Författare :Erik Backhaus; Göteborgs universitet.; Gothenburg University.; [2011]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Streptococcus pneumoniae; epidemiology; risk factors; pneumonia; meningitis; serotype; clonal complex;

    Sammanfattning : Streptococcus pneumoniae is a major cause of disease, ranging from uncomplicated respiratory infections to severe invasive pneumococcal disease (IPD), including bacteraemic pneumonia, septicaemia with unknown focus and meningitis. Case fatality rate (CFR) remains high and antibiotic resistance is increasing globally. S. LÄS MER

  2. 2. Phenotypic antibody discovery and mining of complex antibody libraries

    Detta är en avhandling från Department of Immunotechnology, Lund University

    Författare :Anne Ljungars; [2019-12-19]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Antibody discovery; Phage display; Phenotypic screening; Cell selection; Deep mining; Complex phage pools;

    Sammanfattning : Therapeutic antibodies are the fastest growing class of drugs but suffer from a crowded target-space where many antibodies, against a few targets, are developed in parallel. The aim of this thesis is to find methods to enable discovery of novel antibody-target combinations and thereby increase the target-space. LÄS MER

  3. 3. Structural Basis of Immune Receptor Binding by Staphylococcal Superantigens

    Detta är en avhandling från Department of Experimental Medical Science, Lund Univeristy

    Författare :Karin Rödström; [2014]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Superantigen; X-ray Crystallography; T cell receptor; Major histocompatibility complex;

    Sammanfattning : Superantigens (SAgs) are toxins capable of inducing a massive immune response, leading to severe disease. They are secreted by the bacteria Staphylococcus aureus and Streptococcus pyogenes, which produce the staphylococcal enterotoxins and streptococcal pyogenic exotoxins, respectively. LÄS MER

  4. 4. Molecular epidemiology of streptococcus agalactiae mobile elements as genetic markers

    Detta är en avhandling från Umeå : Klinisk mikrobiologi

    Författare :Shi-Lu Luan; Umeå universitet.; [2006]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Streptococcus agalactiae; group II intron GBSi1 ; multilocus sequence typing; capsular serotype; population structure; MEDICINE Microbiology; immunology; infectious diseases Microbiology Clinical bacteriology; MEDICIN Mikrobiologi; immunologi; infektionssjukdomar Mikrobiologi Klinisk bakteriologi;

    Sammanfattning : Streptococcus agalactiae, also designated group B streptococcus (GBS), is a Gram-positive coccus, and it is an important pathogen that causes invasive disease in neonates, pregnant adults, and non-pregnant adults with predisposing conditions. The group II intron GBSi1 is one of the major mobile genetic elements identified in S. agalactiae. LÄS MER

  5. 5. Analysis of chromosomal rearrangements and gene copy number changes in breast cancer cells

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Oncology-Pathology

    Författare :Pär Lundin; Karolinska Institutet.; Karolinska Institutet.; [2010]

    Sammanfattning : Genome changes in terms of numerical chromosomal aberrations and structural rearrangements, including deletions, amplifications and translocations, gradually accumulate in the genome during tumor development. These genomic changes are likely to play an important role in the process of tumor progression. LÄS MER