Sökning: "clomiphene"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet clomiphene.

  1. 1. Analysis of DNA adducts formed by tamoxifen and related antiestrogenic and estrogenic compounds in rats

    Författare :Heli Rajaniemi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :DNA adducts; 32P-postlabelling; tamoxifen; toremifene; diethylstilbestrol; clomiphene; triparanol; raloxifene; antiestrogen; estrogen; SERM; genotoxicity; cancer;

    Sammanfattning : The work presented herein has focused on DNA adduct formation by the non-steroidal antiestrogen tamoxifen and its analogues. Tamoxifen, [(Z)-1-{4-[2-(dimethylamino)-ethoxy]phenyl}-1,2-diphenyl-1-butene], is widely used in the treatment of breast cancer and its recognised side effect is endometrial cancer. LÄS MER

  3. 2. Endocrine and therapeutic aspects of infertile women with the polycystic ovary syndrome

    Författare :Margareta Fridström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :cost-effectiveness; FSH threshold; glucocorticoids; granulosa cells; infertility; in vitro fertilisation; obesity; ovulation induction; polycystic ovary syndrome; pregnancy complications;

    Sammanfattning : Fertility treatment with gonadotrophins in infertile clomiphene resistant women with the polycystic ovary syndrome (PCOS) is troublesome with an unpredictive ovarian response. The purpose of this study was to elucidate aspects of ovarian sensitivity and to evaluate treatment efficiency and costs of ovulation induction (OI) and in vitro fertilisation (IVF), as well as pregnancy outcome after infertility treatment in patients with PCOS. LÄS MER

  4. 3. Endogenous and exogenous hormonal factors in female cancers : studies of risk and prognosis

    Författare :Chantal Claudine Orgéas; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Extensive evidence points to hormonal influences which play a critical role in the development and progression of breast, ovarian and endometrial or uterine cancers. These cancers share many common hormonal features, which are crucial in the etiology and subsequent development of these cancers. LÄS MER

  5. 4. Endometriosis and ovarian reserve : inflammation and prognostic markers

    Författare :Henrik Falconer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Endometriosis; infertility; baboon; animal model; FSH; AMH; ovarian reserve;

    Sammanfattning : Introduction: Endometriosis is a common, benign gynecological disease, associated with pelvic pain and infertility. It is generally thought to be caused by retrograde shedding of menstrual tissue with subsequent attachment to peritoneal surfaces. LÄS MER

  7. 5. Economic aspects of infertility treatment

    Författare :Maria Granberg; Göteborgs universitet; []
    Nyckelord :ART; health economy; financing; willingness to pay; cost; cost effectiveness; infertility treatment; IVF; ICSI; donor insemination; polycystic ovary syndrome PCOS ; tubal surgery;

    Sammanfattning : Background: With the expansion of IVF into general clinical practise during the 1980's and 1990's, the interest to identify and compare costs of different infertility treatments increased and, in many countries there is an ongoing debate about whether or not in vitro fertilisation (IVF) and other assisted reproductive techniques (ART) should be covered by national health insurance schemes. Objective: The aim of the present study was to examine aspects of cost in relation to effectiveness and benefits of infertility treatment, with particular emphasis on in-vitro fertilisation. LÄS MER