Sökning: "clinical research protocol"

Visar resultat 1 - 5 av 158 avhandlingar innehållade orden clinical research protocol.

  1. 1. SOD1 misfolding and aggregation in ALS : in the light of conformation-specific antibodies

    Författare :Manuela Lehmann; Jonathan D. Gilthorpe; Stefan L. Marklund; Thomas Brännström; Ulrika Nordström; Elizabeth Fisher; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALS; antibodies; SOD1; disordered SOD1; patient-derived models; low oxygen tension; Immunotherapy;

    Sammanfattning : Mutations in the superoxide dismutase 1 (SOD1) gene are linked to the progressive neurodegenerative disease amyotrophic lateral sclerosis (ALS). ALS-associated mutations affect the stability of the SOD1 protein and promote its unfolding. As a consequence, disordered SOD1 species can misfold and accumulate into insoluble aggregates. LÄS MER

  3. 2. Testing Pills, Enacting Obesity : The work of localizing tools in a clinical trial

    Författare :Petra Jonvallen; Boel Berner; Claes-Fredrik Helgesson; Linköpings universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Invisible work; contract research organisation; standardization; articulation work; production tasks; enactment; evidence based medicine; clinical trials; clinical research protocol; rationalizing tools; obesity; pharmaceutical production; clinical practice; medicalisation; Övervikt; klinisk prövning; Technology and social change; Teknik och social förändring; Genus och teknik;

    Sammanfattning : This study examines tools and practices involved in a large scale and multi-sited clinical trial of a potential drug against obesity. Two tools are in focus: a clinical research protocol and a computer control system. LÄS MER

  4. 3. Depression in teenagers and young adults : foundational studies of the new treatment paradigm TARA: Training for Awareness, Resilience, and Action

    Författare :Erik Ekbäck; Eva Henje Blom; Ida Blomqvist; Jenny Molin; Inga Dennhag; Thorbjörn Lundberg; Elizabeth McCauley; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Depression; adolescents; young adults; medical students; mental health; anxiety; psychological stress; qualitative research; randomization; yoga; mindfulness; psychotherapy; antidepressant drugs; biomarkers; clinical trial; feasibility studies; online intervention; reliability; validity; confirmatory factor analysis; measurement invariance; barn- och ungdomspsykiatri; Child and Youth Psychiatry;

    Sammanfattning : Introduction: Depression in adolescents and young adults is an increasing global health concern and available treatments are not convincingly effective. It is therefore important to develop and test novel treatments to improve treatment outcomes. LÄS MER

  5. 4. Electrical Bioimpedance Cerebral Monitoring: Fundamental Steps towards Clinical Application

    Författare :Fernando Seoane Martinez; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedical Instrumentation; Ischemia; Hypoxia; Non-invasive Monitoring; Electrical Bioimpedance Spectroscopy; Stroke; Impedance Measurements; Brain Monitoring;

    Sammanfattning : Neurologically related injuries cause a similar number of deaths as cancer, and brain damage is the second commonest cause of death in the world and probably the leading cause of permanent disability. The devastating effects of most cases of brain damage could be avoided if it were detected and medical treatment initiated in time. LÄS MER

  7. 5. On the use of Phantom Motor Execution for the treatment of Phantom Limb Pain

    Författare :Eva Lendaro; Chalmers tekniska högskola; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amputation; Randomized Controlled Clinical Trial.; Phantom Limb Sensations; Phantom Limb Pain; Phantom Motor Execution;

    Sammanfattning : Phantom limb pain (PLP) is a common complaint among amputees and despite having been studied for centuries, it remains a mysterious object of debate among researcher. To date, a vast number of ways to treat PLP has been proposed in the literature, however none of them has proven to be universally effective, thus creating uncertainty on how to operate clinically. LÄS MER