Sökning: "clevidipine"

Hittade 4 avhandlingar innehållade ordet clevidipine.

  1. 1. Time dependency in the protection from myocardial injury after myocardial ischemia and reperfusion : new insights from experimental studies with the ultrashort-acting calcium antagonist clevidipine

    Författare :Daisuke Segawa; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Myocardial ischemia; reperfusion; calcium antagonist; clevidipine; preconditioning; experimental studies; rat; pig.;

    Sammanfattning : Interruption of the coronary blood flow causes myocardial ischemia and, after a critical time period, myocardial cell death. Accordingly, early reinstitution of arterial blood flow is necessary to minimize the damage. LÄS MER

  3. 2. The pharmacokinetics and pharmacodynamics of clevidipine, a new ultrashort-acting calcium antagonist, in different animal species and man

    Författare :Hans Ericsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; Biopharmaceutics; biofarmaci;

    Sammanfattning : Clevidipine is a new ultrashort-acting calcium antagonist of the dihydropyridine type developed for reduction and control of blood pressure in connection with cardiac surgery. The aim of this thesis was to characterise the in vitro hydrolysis rate of clevidipine in different biological matrices and the pharmacokinetics and pharmacodynamics in animal species and various human populations. LÄS MER

  4. 3. The importance of nitric oxide bioavailability and endothelial mechanisms for cardioprotection by pharmacological intervention during myocardial ischaemia and reperfusion

    Författare :Andrey Gourine; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :ATP sensitive K channels; endothelin-1; clevidipine; ETA receptor antagonist; glibenclamide; 5-hydroxydecanoic acid; infarct size; ischaemia; myeloperoxidase; nitric oxide; nitric oxide synthase; pig; preconditioning; rat; reperfusion.;

    Sammanfattning : Myocardial ischaemia initiates complex severe cellular changes and, after a critical time period, myocardial cell death. Despite that restitution of coronary blood flow is an absolute pre-requisite for tissue survival, myocardial reperfusion per se will also increase irreversible damage in the jeopardised myocardium. LÄS MER

  5. 4. Porcine myocardial ischemia-reperfusion studies on cardioprotection, ventricular arrhythmia and electrophysiology

    Författare :Jacob Odenstedt; Göteborgs universitet; []
    Nyckelord :porcine; myocardial ischemia; ventricular arrhythmia; sudden cardiac death; electrophysiology; vectorcardiography; endocardial mapping; spinal cord stimulation;

    Sammanfattning : Background: Coronary artery disease is the primary cause of death in adults in the industrialised world and ventricular fibrillation associated with myocardial ischemia is the main cause of sudden cardiac death. Restoration of blood flow and preservation of myocardial integrity throughout ischemia and reperfusion is essential to improve clinical outcome. LÄS MER