Sökning: "cleavage"
Visar resultat 6 - 10 av 526 avhandlingar innehållade ordet cleavage.
6. Assembly and proteolytic cleavages of gel-forming mucins
Sammanfattning : Gel-forming mucins are large glycoproteins constituting the main structural component of themucus layer protecting epithelial surfaces of the body. This thesis aims to a deeper understandingof how gel-forming mucins are synthesized and assembled, and how they may interact with othermolecules. LÄS MER
7. Haptoglobin: Biosynthesis and Evolution
Sammanfattning : Haptoglobin (Hp) is a serum protein known for its ability to form a tight complex with hemoglobin (Hb) and thereby inhibiting the oxidative activity of Hb. Mammalian Hp is synthesized as a precursor (proHp) that undergoes proteolytic cleavage by a previously unidentified enzyme in the endoplasmic reticulum (ER). LÄS MER
8. Lewis acid promoted endocyclic cleavage of glycosides and related acetals
Sammanfattning : This thesis is a summary of five papers concerning endocyclic cleavage of glycosides and related acetals. Simple lactol ethers undergo endocyclic cleavage to give acyclic chain extended products on treatment with organoaluminium and organotitanium reagents. LÄS MER
9. TRAF6, a key regulator of TGFβ-induced oncogenesis in prostate cancer
Sammanfattning : Prostate cancer is the most common cancer in men, with the incidence rapidly increasing in Europe over the past two decades. Reliable biomarkers for prostate cancer are currently unavailable. Thus, there is an urgent need for improved biomarkers to diagnose prostate cancer at an early stage and to determine the best treatment options. LÄS MER
10. Modulation of PDGF receptors function by posttranslational modifications
Sammanfattning : The platelet-derived growth factor receptors (PDGFRs) play important roles in multiple cellular processes including cell survival, cell growth and cell migration. Dysregulation of PDGFRs causes aberrant PDGF signaling, which leads to various diseases. LÄS MER