Sökning: "class II transactivator"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden class II transactivator.

  1. 1. Genetic dissection of models for neuroinflammation and neurodegeneration

    Författare :Karin Harnesk; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Many central nervous system (CNS) diseases are characterized by inflammation and nerve cell loss, but the exact relationship between these phenomena is not known. The complex etiology of CNS disorders includes a genetic component. LÄS MER

  3. 2. Positional identification and functional analysis of genes regulating autoimmune arthritis

    Författare :Anthony Chun Yeung Yau; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The major histocompatibility complex (MHC) is the most gene-dense and polymorphic region in the human genome with strong associations to many autoimmune disorders, including rheumatoid arthritis (RA). However, even the genetic association between MHC and RA was known more than 40 years ago, we still have not fully explained the functional roles of the MHC genes and identified the underlying specific polymorphisms. LÄS MER

  4. 3. Genetic regulation of nerve injury-induced neurodegeneration and inflammation

    Författare :Maria Swanberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neurodegeneration and inflammation in the central nervous system (CNS) are hallmarks of several neurological disorders, including multiple sclerosis (MS), Alzheimer’s disease and Parkinson’s disease. The susceptibility of an individual to these conditions is complex, i.e. influenced by both genetic and environmental factors. LÄS MER

  5. 4. Genetics and inflammation in nerve injury-induced neurodegeneration

    Författare :Olle Lidman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Axotomy; Motoneuron; Neurodegeneration; Immunity; Microglia; MHC; QTL Mapping.;

    Sammanfattning : Neurodegeneration and inflammation are characteristic of many diseases of the central nervous system (CNS) and understanding the molecular networks that regulate these processes is of central importance for the development of effective therapies. Although the CNS has traditionally been regarded as an immuno privileged organ, immune reactions, including components of both local innate and systemic immunity, do occur in this tissue. LÄS MER

  7. 5. Exploring early development and regenerative medicine using CRISPR/Cas9

    Författare :Nerges Winblad; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : With their intrinsic capacity to self-renew and their potential to differentiate to specialized tissues, human embryonic stem cells (hESCs) have many applications in the fields of cell therapy and developmental biology. By applying clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9) genome engineering on selected genes in hESCs, we are able to create cells with desired characteristics. LÄS MER