Sökning: "claes andreasson"
Visar resultat 1 - 5 av 6 avhandlingar innehållade orden claes andreasson.
1. Ligand-activated proteolysis in nutrient signaling
Sammanfattning : Cells respond to changing nutrient availability and make adjustments in physiological processes. Central for making proper adjustments is the ability to execute appropriate changes in patterns of gene expression. LÄS MER
2. Hsp70 nucleotide exchange factor Fes1 is essential for protein quality control in Saccharomyces cerevisiae
Sammanfattning : .... LÄS MER
3. Regulation of Hsp70 function by nucleotide-exchange factors
Sammanfattning : Protein folding is the process in which polypeptides in their non-native states attain the unique folds of their native states. Adverse environmental conditions and genetic predisposition challenge the folding process and accelerate the production of proteotoxic misfolded proteins. LÄS MER
4. Regulation of cellular Hsp70 : Proteostasis and aggregate management
Sammanfattning : Proteins have to be folded to their native structures to be functionally expressed. Misfolded proteins are proteotoxic and negatively impact on cellular fitness. To maintain the proteome functional proteins are under the constant surveillance of dedicated molecular chaperones that perform protein quality control (PQC). LÄS MER
5. Controlling protein homeostasis through regulation of Heat shock factor 1
Sammanfattning : In order to thrive in a changing environment all organisms need to ensure protein homeostasis (proteostasis). Proteostasis is ensured by the proteostasis system that monitors the folding status of the proteome and regulates cell physiology and gene expression to counteract any perturbations. LÄS MER