Sökning: "cisterna magna"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden cisterna magna.

  1. 1. Central nervous modulation of pain - a clinical and experimental study

    Författare :Christopher Lundborg; Göteborgs universitet; []
    Nyckelord :pain; head and neck; cisterna magna; baroreflex; noradrenaline; GDNF; co-cultured astrocytes; naloxon; osteoarthritis; calcium;

    Sammanfattning : This series of studies addresses several conceptual issues in modern pain therapy related to the contemporary understanding of mechanisms and modulators involved in the pain sensation. Novel invasive therapy for severe pain, neurogenic interactions, humoral regulators and cellular responses were studied. LÄS MER

  3. 2. Migration of molecules in the brain : focus on the extracellular space and the cerebrospinal fluid

    Författare :Malin Höistad; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Volume transmission; rat; diffusion; striatum; dual-probe microdialysis; delivery; recovery; clearance; uptake; dopamine; metabolism; radiotracer; mannitol; cisterna magna; opioids; peptides; betaendorphin; mu-opioid receptors; mismatch; TH; DBH; immunohistochemistry; fear.;

    Sammanfattning : Three different molecules and three different experimental models were used to study the migration of molecules in the rat brain: a neurotransmitter- dopamine, an extracellular market- mannitol, and a neuropeptide beta-endorphin. Two models in vivo were used to study the diffusion and migration of molecules: dual-probe rnicrodialysis in the striatum, and direct intrastriatal microinjections followed by cerebrospinal fluid sampling from the cisterna magna. LÄS MER

  4. 3. The Relation between Serotonergic Biomarkers and Behaviour : – studies on human primates, non-human primates and transgenic mice

    Författare :Hanna-Linn Wargelius; Dan Larhammar; Lars Oreland; Claudia Fahlke; Elias Eriksson; Uppsala universitet; []
    Nyckelord :Serotonin; MAO-A; 5-HTT; MAO-B; alcohol; ADHD; MEDICINE; MEDICIN; Medicin; Medicine; Neuroscience; Neurovetenskap;

    Sammanfattning : Rationale: The serotonergic system is involved in the modulation of emotion and plays an important role for personality and vulnerability for psychiatric disorders. In the papers included in this thesis, we investigate three biological factors that have been studied in relation to psychiatric symptoms: Platelet monoamine oxidase B (MAO-B) activity, and variations in the MAO-A and the serotonin transporter (5HTT) genes. LÄS MER

  5. 4. Neuro-immune communication: role of the vagus nerve : an electrophysiological study

    Författare :Violeta Bucinskaite; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :cholecystokinin; CCKA; CCKB; cytokines; IL-1[beta]; illness; nerve activity; NIDDM; OLETF; the vagus; vagotomy;

    Sammanfattning : Defence mechanisms involve close interactions between the nervous and immune systems following an immune challenge. The vagal pathways which modulate major visceral functions under normal conditions are also important neural pathways for the transmission of information on peripheral conditions to the CNS. LÄS MER

  7. 5. Pathophysiology of subarachnoid hemorrhage in the rat

    Författare :Giselle F Prunell dos Santos; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Apoptosis; cell death; cerebral blood flow; cerebral metabolism; inflammation; NMDA receptor subunits; subarachnoid hemorrhage.;

    Sammanfattning : Subarachnoid hemorrhage (SAH) causes brain damage, but the underlying mechanisms are poorly understood. An obstacle in SAH research is the lack of an adequate animal model. In this thesis, we developed a new approach to simulate SAH that involves the injection of blood into the prechiasmatic cistern of the rat. LÄS MER