Sökning: "chymase"
Visar resultat 6 - 10 av 21 avhandlingar innehållade ordet chymase.
6. Mast cells and its crosstalk with mesenchymal cells in chronic lung diseases
Sammanfattning : .... LÄS MER
7. Sculpted through Time : Evolution and Function of Serine Proteases from the Mast Cell Chymase Locus
Sammanfattning : Immune cells like NK cells, T cells, neutrophils and mast cells store high amounts of granule serine proteases, graspases. Graspases are encoded from the mast cell chymase locus. The human locus holds four genes: α-chymase, cathepsin G, and granzymes H and B. In contrast, the mouse locus contains at least 14 genes. LÄS MER
8. Hematopoietic Serine Proteases from the Mast Cell Chymase and Tryptase Loci - a Functional and Evolutionary Analysis
Sammanfattning : Mast cells are key effector cells in allergic and inflammatory diseases. However, their primary role is most likely in host defence against parasitic and bacterial infections. Mast cells are a particularly rich source of serine proteases. LÄS MER
9. The Role of Fc gamma Receptors and Mast Cell Chymase in Autoimmune Arthritis
Sammanfattning : In autoimmune diseases such as rheumatoid arthritis (RA), self-reactive antibodies are present at high levels, which contributes to disease pathogenesis. The antibodies mediate their effect predominantly by binding to Fc gamma receptors (FcγR) on various leukocytes, such as monocytes, macrophages and mast cells, where FcγR ligation leads to cell activation. LÄS MER
10. Serglycin-dependent mast cell-specific proteases and their potential interactions with Giardia intestinalis
Sammanfattning : Mast cells are located in mucosal and connective tissues throughout the body where they play important roles in immune reactions towards infections. Mast cell deficiency results in failure of clearance of the non-invasive intestinal protozoan parasite Giardia intestinalis in mice, but the mast cell-driven mechanisms remain poorly understood. LÄS MER
