Sökning: "chronic toxicity"

Visar resultat 16 - 20 av 64 avhandlingar innehållade orden chronic toxicity.

  1. 16. Interactions with pain-related systems - Towards new electrical treatments for chronic pain

    Författare :Matilde Forni; NanoLund: Centre for Nanoscience; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; High definition brain stimulation; Periaqueductal gray matter; Pain systems; Pain models;

    Sammanfattning : Background. Persistent intolerable pain is still an unsolved issue with a huge socioeconomic impact. To develop appropriate treatments, it is crucial to understand the complex mechanisms underlying pain and how they change during sustained pain stimuli or during pathological conditions. LÄS MER

  3. 17. Toxicity and biocompatibility of nanoparticles, and studies on oxidative stress and DNA damage

    Författare :Ylva Rodhe; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Oxidative stress is associated with several diseases, either as a cause or a consequence. Chronic kidney disease (CKD) is one example of a disease in which elevated levels of oxidative stress are frequently reported. LÄS MER

  4. 18. Cellular Responses to Arsenite and Cadmium - Mechanisms of Toxicity and Defense in Saccharomyces cerevisiae

    Författare :Therese Jacobson; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; arsenic; arsenite; cadmium; glutathione; extracellular defense; protein aggregation; chaperones; proteasome; Saccharomyces cerevisiae;

    Sammanfattning : All biological systems have to cope with a wide range of metals that are present in the environment. Metals can be essential or beneficial for life, inert or non-essential and toxic, often depending on their chemical form and concentration. Most organisms have evolved defense mechanisms in order to deal with toxic metals. LÄS MER

  5. 19. When the Rubber Meets the Road -Ecotoxicological Hazard and Risk Assessment of Tire Wear Particles

    Författare :Anna Wik; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; tire wear; tire particles; rubber; leaching tests; ecotoxicity tests; Daphnia magna; Ceriodaphnia dubia; Pseudokirchneriella subcapitata; Danio rerio; toxicity identification evaluation; detention ponds; hazard assessment; risk assessment;

    Sammanfattning : Large amounts of rubber particles are dispersed into the environment due to tire wear. The rubber contains a wide range of chemicals, including several of environmental concern. The purpose of this th.. LÄS MER

  7. 20. The role of fibroblast growth factor-23 in chronic kidney disease-mineral and bone disorder

    Författare :Majd A. I. Mirza; Tobias Larsson; Tilman Drüeke; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; FGF23; FGF-23; CKD; CKD-MBD; cardiovascular disease; vascular function; atherosclerosis; hypertrophy; LVMI; LVH; fractures; bone; fat mass; obesity; apolipoproteins; cholesterol; lipids; Kidney diseases; Njursjukdomar; Cardiovascular medicine; Kardiovaskulär medicin; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Fibroblast growth factor-23 (FGF23) was initially identified as the causative factor of autosomal dominant hypophosphatemic rickets. Further studies confirmed that FGF23 is predominantly expressed in the osteocytes and osteoblasts of bone and that circulating FGF23 acts on the kidney to inhibit renal phosphate reabsorption and 1,25(OH)2D3 hydroxylation. LÄS MER