Sökning: "chromosome-specific gene regulation"
Hittade 3 avhandlingar innehållade orden chromosome-specific gene regulation.
1. Jack of all trades, master of none : the multifaceted nature of H3K36 methylation
Sammanfattning : Post-translational modifications of histones enable differential transcriptional control of the genome between cell types and developmental stages, and in response to environmental factors. The methylation of Histone 3 Lysine 36 (H3K36) is one the most complex and well-studied histone modifications and is known to be involved in a wide range of molecular processes. LÄS MER
2. Aneuploidy compensatory mechanisms and genome-wide regulation of gene expression in Drosophila melanogaster
Sammanfattning : Stimulation or repression of gene expression by genome-wide regulatory mechanisms is an important epigenetic regulatory function which can act to efficiently regulate larger regions or specific groups of genes, for example by compensating for loss or gain of chromosome copy numbers. In Drosophila melanogaster there are two known chromosome-wide regulatory systems; the MSL complex, which mediates dosage compensation of the single male X-chromosome and POF, which stimulates expression from the heterochromatic 4th chromosome. LÄS MER
3. Chromosome-specific adaptations of RNA stability and the roles of the roX RNAs in dosage compensation
Sammanfattning : Sex chromosomes evolved from an ancient pair of autosomes and the Y chromosome lost most of its genetic information in the process. This created two kinds of genomic imbalances: the first one between males (XY) and females (XX) and the second one between the sex chromosomes and the autosomes (X:AA). LÄS MER