Sökning: "chromosomal alterations"
Visar resultat 16 - 20 av 81 avhandlingar innehållade orden chromosomal alterations.
16. Approaches for the localization and identification of human cancer genes
Sammanfattning : Chromosomal aberrations have been recognized as important observations that underpin the concept of a mutator phenotype in cancer. In this thesis, two basic strategies were applied to map the location of cancer-related genes in several types of cancers. LÄS MER
17. Molecular Characterization of Diffuse Large B-cell Lymphoma and Aspects of Transformation
Sammanfattning : Lymphomas are a heterogeneous group of neoplasias originating from B- or T-lymphocytes. In this thesis, we determined the genetic and immunophenotypic characterization of DLBCL and their prognostic impact. LÄS MER
18. Studies on the molecular mechanisms of resistance to fluoroquinolones and carbapenems in selected bacterial species
Sammanfattning : The emergence of mutant bacteria with multi-resistant phenotype, no longer responsive to any of the available therapeutic agents is a growing concern. We have investigated the resistance mechanisms to two classes of antibacterials with broad spectrum of activity, carbapenems and fluoroquinolones. LÄS MER
19. Genomic instability and tumor progression : a cytochemical, molecular biological and cytogenetic study of human tissue from uterine cervix, colon, breast and ovary
Sammanfattning : Disruption of cell cycle checkpoint control is believed to be common in human carcinomas. To elucidate how cell cycle defects and genomic instability cooperate we investigated the pathogenesis of carcinomas by using four different models of tumor progression in human tissue samples i.e. from the uterine cervix, colon, breast and ovary. LÄS MER
20. Identification of protein signatures of genomic stability/instability in epithelial cancers
Sammanfattning : Aneuploidy is a consistent genetic alteration of the cancer genome. At early steps in the sequence of malignant transformation during human tumorigenesis, chromosomal aneuploidies can be the first detectable genetic aberrations found. LÄS MER