Sökning: "chromatin organization"

Visar resultat 6 - 10 av 62 avhandlingar innehållade orden chromatin organization.

  1. 6. Decoding the Structural Layer of Transcriptional Regulation : Computational Analyses of Chromatin and Chromosomal Aberrations

    Författare :Robin Andersson; Jan Komorowski; Jan Dumanski; Claes Wadelius; Anders Krogh; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chromatin; Nucleosome positioning; Histone modifications; Chromosomal aberrations; Transcriptional regulation; Array-CGH; Next generation sequencing; ChIP-chip; Bioinformatics; Bioinformatik; Bioinformatics; Bioinformatik;

    Sammanfattning : Gene activity is regulated at two separate layers. Through structural and chemical properties of DNA – the primary layer of encoding – local signatures may enable, or disable, the binding of proteins or complexes of them with regulatory potential to the DNA. LÄS MER

  3. 7. Chromatin Dynamics in the Fission Yeast, Schizosaccharomyces pombe

    Författare :Carolina Kristell; Pernilla Bjerling; Per Sunnerhagen; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chromatin; Gene induction; Silencing; Subnuclear localization; Stress; Molecular biology; Molekylärbiologi; Molekylär genetik; Molecular Genetics;

    Sammanfattning : In the eukaryotic cell nucleus, spatial organization and dynamics of the genome is important in the regulation of gene expression. This thesis describes the use of the fission yeast, Schizosaccharomyces pombe, to study chromatin regulation and dynamics. We used nitrogen starvation to induce transcription of genes in fission yeast cells. LÄS MER

  4. 8. Epigenetic Regulation of Higher Order Chromatin Conformations and Gene Transcription

    Författare :Anita Göndör; Reinald Fundele; Thomas Graf; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Genomic imprinting; Chromatin; Epigenetics; Cancer; Developmental biology; Utvecklingsbiologi;

    Sammanfattning : Epigenetic states constitute heritable features of the chromatin to regulate when, where and how genes are expressed in the developing conceptus. A special case of epigenetic regulation, genomic imprinting, is defined as parent of origin-dependent monoallelic expression. LÄS MER

  5. 9. Epigenetic Regulation of Genomic Imprinting and Higher Order Chromatin Conformation

    Författare :Gholamreza Tavoosidana; Rolf Ohlsson; Job Dekker; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Epigenetic; Imprinting; Chromatin; CTCF; H19 ICR; 4C; Utvecklingsbiologi; Biology; Biologi;

    Sammanfattning : The genetic information encoded by the DNA sequence, can be expressed in different ways. Genomic imprinting is an epigenetic phenomenon that results in monoallelic expression of imprinted genes in a parent of origin-dependent manner. Imprinted genes are frequently found in clusters and can share common regulatory elements. LÄS MER

  7. 10. The Epigenetics of Gene Transcription and Higher Order Chromatin Conformation

    Författare :Vijay Kumar Tiwari; Rolf Ohlsson; Terumi Kohwi-Shigematsu; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; DNA-protein interactions; Nuclear organization; Transcriptional regulation; Higher order chromatin conformations; Epigenetic reprogramming; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi;

    Sammanfattning : It is becoming increasingly clear that long-range control of gene expression is mediated through direct physical interactions between genes and regulatory elements, either intra- or interchromosomally. In addition to transcriptional initiation, formation of active chromatin hubs seem to be crucial for increased transcriptional efficiency as well as insulation from neighbouring heterochromatic environment. LÄS MER