Sökning: "chromatin organization"

Visar resultat 16 - 20 av 62 avhandlingar innehållade orden chromatin organization.

  1. 16. An RNA story, from chromatin to protein

    Författare :Davide Maria Trevisan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : RNA functions expand well over just coding for protein effectors. Non-coding RNAs oversee translation, RNA processing, and spatial organization of the cellular space, therefore participating in the regulation of almost any cellular process. To add a further layer of complexity, both coding and non-coding RNAs are extensively modified. LÄS MER

  3. 17. Polyamines are involved in the regulation of S phase and DNA synthesis

    Författare :Kersti Alm; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Djurfysiologi; Animal physiology; cell cycle regulation; p53; DNA strand breaks; replicon organization; topoisomerase II;

    Sammanfattning : Our research group has previously shown that treatment with the polyamine biosynthesis inhibitors a-difluoromethylornithine (DFMO) or amidinoindan-1-one 2´-amidinohydrazone (CGP 48664) inhibited S phase progression before any other cell cycle phase was affected. This study was undertaken to further investigate the role of polyamines in the regulation of S phase progression and DNA synthesis. LÄS MER

  4. 18. Studies on genetic aberrations as possible predictors of the outcome of assisted reproduction

    Författare :Mona Bungum; Malmö Reproduktionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; assisted reproduction; IUI; Sperm chromatin; ICSI; intra-individual variation; fertilisation failure genetic aberration; Protein C inhibitor gene; sperm DNA damage SCSA; IVF;

    Sammanfattning : Traditionally, diagnosis of male infertility has relied upon microscopic assessment of semen. The normality criteria set by the World Health Organization (WHO) in regard to sperm concentration, motility and morphology are, however, poor predictors of fertility. LÄS MER

  5. 19. Regulation of chromatin transitions in the 3D architecture of the nucleus

    Författare :Honglei Zhao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The thesis explores the dynamic features and functions of chromatin crosstalk in the 3D nucleus space, with a focus on the regulation of chromatin transitions. In Paper I we employed the circular chromosome conformation capture assay (4C) and Chromatin in situ Proximity (ChrISP) technique to uncover an inter-chromosomal chromatin fiber interactome comprising both transcriptionally active circadian genes and repressed lamina-associated domains (LADs). LÄS MER

  7. 20. Modulating chromatin by transcription and nucleosome turnover : a genome-wide study in fission yeast

    Författare :Laia Sadeghi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Eukaryotic DNA is wrapped around histone proteins to form a nucleosome, the basic structural unit of chromatin. Multiple levels of chromatin organization are required to compact DNA into chromosomes, to ensure an accurate cell division. LÄS MER