Sökning: "chromatin organization"
Visar resultat 11 - 15 av 62 avhandlingar innehållade orden chromatin organization.
11. Interplay of chromatin remodeling, transcriptional regulation, and nuclear organization
Sammanfattning : Transcription is regulated on different levels to ensure that genes are expressed at the correct time and in the amounts required. At the chromatin level, DNA is wound onto histone proteins, forming nucleosomes that influence accessibility of DNA elements. LÄS MER
12. BEN-solo proteins in genome architecture and function
Sammanfattning : Eukaryotic genomes are organized in a complex manner inside the nucleus of each cell. Chromatin insulators are DNA elements that help to fold the linear DNA fiber in three-dimensional space and partition regulatory gene units. LÄS MER
13. Imaging the molecular pathways of neurodegeneration : New pathologies of SCA7
Sammanfattning : Spinocerebellar Ataxia type 7 (SCA7) is a genetic neurodegenerative disease with lethal outcome that affects the cerebellum and retina of patients. This thesis focuses on characterising molecular pathological pathways that cause toxicity and cell death in SCA7. LÄS MER
14. Exploring chromatin organization and transcription in S. pombe and hematopoietic development
Sammanfattning : DNA in the eukaryotic nucleus is organized into histone-DNA complex, so-called chromatin, through forming an array of nucleosomes. Each nucleosome consists of a 147bp DNA wrapped around a histone octamer harboring two of each H2A-H2B and H3-H4. Chromatin is orderly packed several times forming a chromosome structure. LÄS MER
15. Dynamics of higher order chromatin structures
Sammanfattning : During the last few decades, the intensive focus on microscopy observations and genome sequencing analyses has proved that the genomic DNA is packaged in the non-random manner in the nucleus of interphase cells. Accumulated evidence have thus documented that the chromatin organization in 3D plays key roles in central biological processes, such as transcription, replication and DNA repair. LÄS MER