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Visar resultat 1 - 5 av 62 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Transcription regulation across levels of chromatin organization

   Författare :Roshan Vaid; Mattias Mannervik; Goncalo Castelo-Branco; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transcription; chromatin; epigenetics; Drosophila; embryo development; molekylär biovetenskap; Molecular Bioscience;

   Sammanfattning : With advancements in high-throughput sequencing and high-resolution microscopy techniques, the significance of genome organization in transcription regulation is rapidly unveiling. Nonetheless, we are yet far from completely understanding this key relationship. LÄS MER

3. 2. Chromatin Remodeling by BRG1 and SNF2H : Biochemistry and Function

   Författare :Patrik Asp; Ann-Kristin Östlund Farrants; Anthony Imbalzano; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; chromatin; chromatin remodeling; SWI SNF; ISWI; BRG1; SNF2H; Prp8; RNA; transcription; Cell and molecular biology; Cell- och molekylärbiologi;

   Sammanfattning : Chromatin is a highly dynamic, regulatory component in the process of transcription, repair, recombination and replication. The BRG1 and SNF2H proteins are ATP-dependent chromatin remodeling proteins that modulate chromatin structure to regulate DNA accessibility for DNA-binding proteins involved in these processes. LÄS MER

4. 3. The role of nuclear membrane proteins in differentiation and chromatin organization

   Författare :Cecilia Bergqvist; Einar Hallberg; Neus Visa; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; nuclear membrane proteins; chromatin organization; epigenetics; differentiation; stem cells; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : The nuclear envelope, consisting of an outer and an inner nuclear membrane, surrounds the genomic material. The genomic material (chromatin) is highly structured with (transcriptionally inactive) heterochromatin mostly found in the nuclear periphery and (transcriptionally active) euchromatin mostly found in the nuclear interior. LÄS MER

5. 4. Chromatin remodelers and their roles in chromatin organization

   Författare :Annelie Strålfors; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The DNA in the eukaryotic nucleus is organized into a complex DNA-protein structure called chromatin. The basic repeating unit of chromatin is the nucleosome, which consists of 147 bp of DNA wrapped around a histone protein octamer. LÄS MER

7. 5. The role of nuclear envelope proteins in chromatin organization, differentiation and disease

   Författare :Cecilia Bergqvist; Einar Hallberg; Philippe Collas; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Nuclear envelope proteins; chromatin organization; epigenetics; differentiation; quantitative image analysis; Samp1; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : In eukaryotes the genetic material is separated from the cytoplasm by the nuclear envelope (NE), consisting of the outer and inner nuclear membrane, the nuclear lamina and the nuclear pores. The genetic material is highly structured with transcriptionally inactive heterochromatin enriched at the nuclear periphery and transcriptionally active euchromatin in the nuclear interior. LÄS MER