Sökning: "chromatin accessibility"

Visar resultat 21 - 25 av 37 avhandlingar innehållade orden chromatin accessibility.

  1. 21. Importance of the Clr2 protein in heterochromatin formation in the fission yeast Schizosaccharomyces pombe

    Författare :Daniel Steinhauf; Leif Andersson; Uppsala universitet; []
    Nyckelord :Clr2; Yeast; Heterochromatin; Fission yeast; Schizosaccharomyces pombe; Biokemi; Biochemistry;

    Sammanfattning : Epigenetics is an area of biology that studies heritable changes in gene ex- pression without any change in the DNA sequence. The most studied epige- netic mechanisms are DNA methylation, RNA interference and histone mod- ifications. LÄS MER

  3. 22. SOX transcription factors : multifaceted regulators of central nervous system development

    Författare :Cécile Zaouter; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The central nervous system (CNS) is composed of three major cell types, namely neurons, astrocytes and oligodendrocytes that are mainly generated during embryonic stages by multipotent neural progenitor cells (NPCs). The decision of a NPC to remain in a self-renewing, undifferentiated state, or to commit to neuronal or glial differentiation is guided by the combined actions of transcription factors on their downstream target genes. LÄS MER

  4. 23. The Control of the Epigenome

    Författare :Magda Lezcano; Rolf Ohlsson; Matthias Merkenschlager; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biology; Epigenetics; chromosome interactions; replication timing; histone modifications; epigenetic surveillance; Biologi; Biology; Biologi;

    Sammanfattning : The genetic information required for the existence of a living cell of any kind is encoded in the sequence information scripted in the double helix DNA. A modern trend in biology struggles to come to grip with the amazing fact that there are so many different cell types in our body and that they are directed from the same genomic blueprint. LÄS MER

  5. 24. Gene regulatory mechanisms in the oligodendrocyte lineage in development and disease

    Författare :Mandy Meijer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Oligodendrocytes are the myelinating cells of the central nervous system (CNS). They contribute to the neuronal network through the insulation of neuronal axons, facilitating communication between neurons and providing metabolic support. LÄS MER

  7. 25. Unravelling Mechanistic Insights of Eukaryotic Transcriptional Control

    Författare :Johanna Hörberg; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Transcriptional control; Gene expression regulation; DNA supercoiling; DNA methylation; DNA-protein recognition; Basic-Leucine-Zipper transcription factors; Basic-Helix-Loop-Helix transcription factors; Sequence specific DNA plasticity; Transcription factor cooperativity; Cancer; Molecular modelling; Molecular dynamics;

    Sammanfattning : DNA transcription involves the association of multiple proteins with DNA to convert the genetic information into messenger-RNA transcripts, which later will be translated into proteins. Con-trolled regulation of transcription is imperative for preserving the healthy and homeostatic state of cells. LÄS MER