Sökning: "chromatin accessibility"

Visar resultat 16 - 20 av 37 avhandlingar innehållade orden chromatin accessibility.

  1. 16. Characterization of RNA polymerase II subunit Rpb7 in silencing and transcription

    Författare :Ingela Djupedal; Karl Ekwall; Anthony Wright; Olivier Voinnet; Södertörns högskola; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The DNA in eukaryotes is arranged in fibres of chromatin. The chromatin may be more or less compacted and the degree of condensation of the chromatin affects the accessibility of the DNA. The accessibility of the DNA, in turn, affects transcription and gene regulation. LÄS MER

  3. 17. Integrative Modeling of Epigenetic Regulation in Human Disease

    Författare :Xi Lu; Xingqi Chen; Chandrasekhar Kanduri; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioblastoma; Cross-species; Glioblastoma stem cell; Dravet syndrome; ATAC-seq; Single-cell multi-omics technology;

    Sammanfattning : Glioblastoma is the most common and aggressive primary brain tumor. Standard of treatment prove ineffective, leading to tumor recurrence and an average survival rate of 14 months. This treatment resistance is attributed to both inter-tumor and intra-tumor heterogeneity observed across diverse tumor samples and within individual cells. LÄS MER

  4. 18. Decoding the contribution of transcription factors to cell fate determination

    Författare :Bei Wei; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : It is well accepted that transcription factors (TFs) play a crucial role in determining cell identity. Although RNA expression or protein abundance data show that a large fraction of the total TFs are expressed in a given cell, however, only a small set of them is essential for specifying cell identity. LÄS MER

  5. 19. Studies of histone modification systems in Schizosaccharomyces pombe

    Författare :Carolina Bonilla; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The genetic information in every cell is carried in the DNA. In eukaryotes the DNA is wrapped twice around proteins called histones forming a repeating unit called the nucleosome, in fibers known as chromatin. Nucleosomes are folded into higher order structures forming the chromosomes. LÄS MER

  7. 20. Novel FISH methods to unveil genome architecture

    Författare :Ana Mota; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The genome consists of incredibly long DNA strands that encode all the vital information for the cell to function. The DNA inclusion in the very tight nuclear space and, simultaneously, the establishment of a hierarchical organization of the chromatin that favors transcription of certain genes over others, sparked a long-lasting quest to understand the design principles that govern genome architecture. LÄS MER