Sökning: "choroidal"

Visar resultat 1 - 5 av 11 avhandlingar innehållade ordet choroidal.

1. 1. Choroidal neovascularization (CNV) : clinical and experimental aspects

   Författare :Lennart Berglin; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :CNV; angiogenesis; age-related macular degeneration; AMD; aging; surgery; endothelial cells; VEGF; MMP; TIMP; MMP-2; immunohistochemistry; ECM; RPE; Bruch s membrane; wound healing; inflammation; macrophages; in-situ hybridization; mRNA; immature vessels; MMP-9; TIMP- 3; MMP-2 deficiency;

   Sammanfattning : This work comprises different aspects of choroidal neovacularization (CNV); a leading cause of visual loss in the aged. It is an example of angiogenesis and a complication of age-related macular degeneration (AMD) The purpose was to study if patient age influences outcome of CNV surgery, to characterize the cellular content of CNV, to analyze the expression of vascular endothelial growth factor (VEGF) and various matrix metalloproteinases (MMP) and their inhibitors (TIMP) in CNV and to study if MMP-2 influences experimental CNV growth. LÄS MER

3. 2. Phenotypes and genotypes in families with hereditary tapetoretinal degenerations

   Författare :Vesna Ponjavic; Lund Oftalmologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; peripherin.; rhodopsin; cone-rod dystrophy; retinitis pigmentosa; choroideremia; central areolar choroidal dystrophy; mutation screening; full-field electroretinography; Phenotype; genotype; Ophtalmology; Oftalmologi;

   Sammanfattning : The purpose of the study was to characterise the phenotype with emphasis on electroretinography in four different types of hereditary retinal degeneration and to correlate it to a genotype when possible. Two methods were used: full-field electroretinography for objective assessment of retinal function and mutation screening of blood samples for detection of gene alterations. LÄS MER

4. 3. Uveal melanoma : epidemiological and clinical aspects

   Författare :Louise Bergman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Melanoma; uveal; choroidal; epidemiology; population-based registry; incidence; survival; familial; ruthenium brachytherapy;

   Sammanfattning : A major purpose with this thesis was to assess the incidence and mortality rates of uveal melanoma in Sweden during the period 1960 to 1998, using population-based registry data. In total, 2,995 patients (1,541 males and 1,454 females) were diagnosed with uveal melanoma. LÄS MER

5. 4. Interactions between neural retina, retinal epithelium and choroid

   Författare :Lena Ivert; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :RPE; neural retina; basal lamina; Bruch s membrane; choroid; subretinal space; bleb detachment; ICG; FAG; SLO; choroidal blood flow.;

   Sammanfattning : The retinal pigment epithelium (RPE) is a non-replicating monolayer that plays a key role nursing the photoreceptors of the neural retina, regulating fluid movement within the subretinal space, maintaining a basal laminar layer of Bruch s membrane, and influencing the choriocapillaris. This project investigates how surgical manipulation of the retinal epithelial layer influences the neural retina, the choroid and the epithelial layer itself. LÄS MER

7. 5. Investigation of potential prognostic and therapeutic genes in pathologic neovascularization of the retina

   Författare :Parviz Mammadzada; Karolinska Institutet; Karolinska Institutet; Sweden Stockholm Karolinska Institutet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Pathologic angiogenesis of the retina is a hallmark of frequent blinding conditions among the elderly, such as proliferative diabetic retinopathy (PDR) and neovascular age-related macular degeneration (nAMD). The underlying mechanisms are complex. LÄS MER