Sökning: "chondroitin sulfate"

Visar resultat 6 - 10 av 41 avhandlingar innehållade orden chondroitin sulfate.

  1. 6. Syndecan - Regulation and Function of its Glycosaminoglycan Chains

    Författare :Anna S. Eriksson; Dorothe Spillmann; Catherine Merry; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; heparan sulfate; chondroitin sulfate; integrin; cell motility; fibroblast growth factor signaling; pharyngeal cartilage; biosynthesis regulation; Medical Science; Medicinsk vetenskap;

    Sammanfattning : The cell surface is an active area where extracellular molecules meet their receptors and affect the cellular fate by inducing for example cell proliferation and adhesion. Syndecans and integrins are two transmembrane molecules that have been suggested to fine-tune these activities, possibly in cooperation. Syndecans are proteoglycans, i.e. LÄS MER

  3. 7. Interactions between herpes simplex virus type 1 glycoprotein C and cell surface glycosaminoglycans

    Författare :Kristina Mårdberg; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Herpes simplex virus-1; glycoprotein C; virus receptor; glycosaminoglycans; heparan sulfate; chondroitin sulfate;

    Sammanfattning : The cell surface glycosaminoglycan (GAG) heparan sulfate (HS) serves as an initial receptor for herpes simplex virus type 1 (HSV-1) and virus attachment to the HS molecule is mediated by the envelope glycoprotein C (gC). In the first part of this thesis, we aimed to define the HS-binding domain of viral gC. LÄS MER

  4. 8. Large chondroitin sulfate proteoglycans in the axolotl embryo

    Författare :Michael Stigson; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP;

    Sammanfattning : .... LÄS MER

  5. 9. Glycosaminoglycan Biosynthesis in Zebrafish

    Författare :Beata Filipek-Górniok; Lena Kjellén; Johan Ledin; Kay Grobe; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Heparan sulfate; chondroitin dermatan sulfate; biosynthesis; development; N-deacetylase N-sulfotransferase; glycosyltransferases; morpholino; CRISPR-Cas9;

    Sammanfattning : Proteoglycans (PGs) are composed of highly sulfated glycosaminoglycans chains (GAGs) attached to specific core proteins. They are present in extracellular matrices, on the cell surface and in storage granules of hematopoietic cells. LÄS MER

  7. 10. New insights into principles of scaffolds design for bone application

    Författare :Hongji Yan; Tim Bowden; Hong Qian; Martijn van Griensven; Uppsala universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Chondroitin sulfate; hyaluronic acid; pH; cross-linking chemistry; bone morphogenetic protein; lithium; mesenchymal stem cell; in vivo.; Engineering Science with specialization in Nanotechnology and Functional Materials; Teknisk fysik med inriktning mot nanoteknologi och funktionella material;

    Sammanfattning : This thesis presents deeper insights into bone applicable biomaterials’ design. Poor affinity of BMP-2 towards scaffolds required supra-physiological dose administration. Though molecules containing sulfate could sustain BMP-2 release, side effects occurred due to BMP-2 supra-dose, or these sulfate-containing biomolecules. LÄS MER