Sökning: "cholinergic modulation"

Visar resultat 1 - 5 av 29 avhandlingar innehållade orden cholinergic modulation.

  1. 1. Modulation of Neuronal Functions : the Role of SLC10A4

    Författare :Kalicharan Patra; Klas Kullander; Håkan Aldskogius; Per Svenningsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dopamine; acetylcholine; central nervous system; neuromuscular junctions; electrophysiology; monoamine; synaptic transmission; neuromodulation; Neuroscience; Neurovetenskap;

    Sammanfattning : Mental health of a person depends on the correct functioning of the brain. The brain and the spinal cord contain many types of cells, of which one important type are called the neurons. Neurons are special in the way they connect to each other to form large networks. LÄS MER

  3. 2. The role of dopaminergic and cholinergic modulation on the striatal network : a computational investigation

    Författare :Robert Lindroos; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The famous words from the French philosopher René Descartes (1596-1650), “I think therefore I am”, proclaims that since we are thinking we must also exist. At the time when this was stated, very little was known about the main organ involved in thinking, the nervous system. LÄS MER

  4. 3. Regenerating the brain : stem cell differentiation and cholinergic dysfunction in Alzheimer disease

    Författare :Linn Malmsten; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hippocampal neurogenesis in the adult brain is important for learning and memory processes, which are heavily affected in Alzheimer disease (AD). Thus, targeting processes that could stimulate neurogenesis is a logical step in the search for strategies offering neuronal renewal and brain repair. LÄS MER

  5. 4. On cholinergic mechanisms involved in ethanol reinforcement. A behavioral and neurochemical study in rodents

    Författare :Anna Larsson; Göteborgs universitet; []
    Nyckelord :Acetylcholine; Dopamine; Ethanol; Locomotor activity; Microdialysis; Nicotine; Nicotinic acetylcholine receptors; Rodents; Reward;

    Sammanfattning : Alcohol (ethanol) and smoking (nicotine) are commonly co-abused in human beings. Drugs of abuse interact with the brain mesolimbic dopamine system, an important part of the brain reward system. These dopaminergic neurons originate in the ventral tegmental area and project to e.g. LÄS MER

  7. 5. Afferent input to midbrain dopamine neurones and its modulation : an electrophysiological study i vitro

    Författare :Pernilla Grillner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :dopamine neurones; synaptic transmission; NMDA receptors; L-type Ca2 channels; presynaptic inhibition; metabotropic glutamate receptors; muscarine; nicotine;

    Sammanfattning : Dopamine (DA) neurones of the ventral mesencephalon are involved in the control of reward related behaviour, cognitive functions and motor performances, and provide a critical site of action for major categories of neuropsychiatric drugs, such as antipsychotic agents, dependence producing drugs and anti-Parkinson medication. The midbrain DA neurones are mainly located in the substantia nigra pars compacta (SNPC) and the ventral tegmental area (VTA). LÄS MER