Sökning: "cholesterol synthesis"

Visar resultat 11 - 15 av 100 avhandlingar innehållade orden cholesterol synthesis.

1. 11. Post-transplantation Hypercholesterolaemia

   Författare :Osama Al Rayyes; Malmö Institutionen för kliniska vetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; thiazolidinediones; transplantation; low density lipoprotein; insulin; indomethacin; hydrocortisone; fluvastatin; flufenamic acid; Cholesterol; cyclosporine; troglitazone.; Immunology; serology; Immunologi; serologi;

   Sammanfattning : The multidrug regimen, cyclosporine, corticosteroids, and azathioprine, is used in transplantation centres to prevent organ rejection. Several clinical studies have shown that cyclosporine and corticosteroids to cause increases in low density lipoprotein (LDL)-cholesterol, with subsequent development of atherosclerosis. LÄS MER

3. 12. Nutrition in infancy - Clinical studies on dietary intake, metabolism and growth

   Författare :Pia Karlsland Åkeson; Preventiv pediatrik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; urea; triglycerides; protein intake; nutrition; Mediterranean; infant; growth; formula; fat intake; energy intake; diet; C-peptide; cholesterol; breast milk; bioavailability; amino acids; apolipoproteins; weaning; weaning foods; Pediatrics; Pediatri;

   Sammanfattning : Nutrition in infancy - Clinical studies on dietary intake, metabolism and growth Our aims were to try to determine an appropriate formula protein concentration to be used during the second half of infancy and to evaluate the effects on plasma lipids when breast milk was exchanged for formula and/or weaning foods. Both aspects were studied with special regard to the influence of traditional weaning foods. LÄS MER

4. 13. Molecular heterogeneity of prostate cancer bone metastasis

   Författare :Erik Bovinder Ylitalo; Pernilla Wikström; Anders Bergh; Maria Brattsand; Vessela Kristensen; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; CRPC; castration-resistant; androgen receptor; splice variant; abiraterone; cabazitaxel; ABCB1; cholesterol; Mdr1; P-gp; bone metastasis; immune response; metabolism; osteoblast; osteoclast; BMP; methylation;

   Sammanfattning : Castration-resistant prostate cancer (CRPC) develops after androgen deprivation therapy of advanced PC, often with metastatic growth in bone. Patients with metastatic CRPC have very poor prognosis. Growth of CRPC, in most but not all patients, seems to involve androgen receptor (AR) activity, despite castrate levels of serum testosterone. LÄS MER

5. 14. Smith-Lemli-Opitz syndrome : a disorder of cholesterol synthesis : diagnosis, treatment and pathogenetic aspects

   Författare :Lena Starck; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Smith-Lemli-Opitz syndrome; cholesterol; cholesterol treatment; dehydrocholesterols; lathosterol; oxysterols; blood paper specimens; simvastatin; clinical scoring.;

   Sammanfattning : In 1993 it was first suggested that the Smith-Lemli-Opitz syndrome (SLOS), described almost 30 years earlier as a malformation syndrome, is caused by defective synthesis of cholesterol. Hypocholesterolaemia and accumulation of the immediate precursor 7-dehydrocholesterol was consistent with deficient activity of the enzyme in the last step of the synthesis, 7-dehydrocholesterol-7-reductase. LÄS MER

7. 15. Synthesis and Applications of Dynamic Multivalent Nanostructures

   Författare :Kitjanit Neranon; Olof Ramström; Aldrik Velders; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; multivalent nanostructures; self-assembly; metal-ligand exchange; dynamic covalent chemistry; bipyridine derivatives; dendrimers; liposomes; drug delivery; antimicrobial materials; fluorescent probe; plasmonic chemistry; gold surface functionalization; Kemi; Chemistry;

   Sammanfattning : This thesis focuses on the design, synthesis and development of dynamic multivalent nanostructures such as supramolecular dendrimers, liposomes and gold-functionalized nanostructures. These structures can be used for drug delivery and molecular sensing applications. LÄS MER