Sökning: "cholesterol metabolism"

Visar resultat 21 - 25 av 192 avhandlingar innehållade orden cholesterol metabolism.

  1. 21. Role of cholesterol metabolism in hepatic steatosis and glucose tolerance

    Författare :Osman Salih Osman Ahmed; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The liver is the central organ for lipid, lipoprotein and glucose homeostasis, thus hepatic metabolic disturbances can predispose individuals to develop cardiometabolic disorders (CMD) such as atherosclerotic cardiovascular diseases (ASCVD), type 2 diabetes mellitus (T2DM), and nonalcoholic fatty liver disease (NAFLD).The overall aim of this thesis was to expand the knowledge on how genetic and pharmacological interventions on hepatic and intestinal cholesterol metabolism could affect the pathophysiology of CMD. LÄS MER

  3. 22. Effects of growth hormone on cardiovascular risk factors and atherosclerosis

    Författare :Maria Leonsson Zachrisson; Göteborgs universitet; []
    Nyckelord :growth hormone; pituitary deficiency; dietary fat; cholesterol; low density; lipoprotein; intima-media thickness; IL-6; CRP; TNF-á;

    Sammanfattning : Hypopituitary patients with growth hormone (GH) deficiency (GHD) have increasedmorbidity and mortality from cardiovascular disease (CVD). GH treatment has both beneficialand potentially negative cardiovascular effects. LÄS MER

  4. 23. Central adipocyte functions in specialized caveolae

    Författare :Unn Örtegren Kugelberg; Eva Degerman; Linköpings universitet; []
    Nyckelord :Obesity; Overweight; Diabetes; Stroke; Cholesterol metabolism; Fatty acids; MEDICINE; MEDICIN;

    Sammanfattning : Obesity and overweight is an increasing health problem in the world. Besides reducing quality of life obesity is a great risk factor for development of diseases such as type 2 diabetes, cardiovascular disease, and stroke. The adipose tissue is a flexible organ that grows in size if the body is provided with excess energy. LÄS MER

  5. 24. Innate lymphoid cells and cholesterol metabolism in intestinal barrier function

    Författare :Sara Martina Parigi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The intestinal mucosa represents one of the largest barrier sites of our body, having to withstand a constant exposure to a plethora of environmental insults (including dietary compounds, xenobiotics, metabolites and microorganisms). While our body has evolved tolerance/ignorance towards some of these factors deemed beneficial for the host, it requires constant maintenance of epithelial barrier integrity and ability to mount pro-inflammatory responses to protect against potentially harmful environmental insults. LÄS MER

  7. 25. Molecular mechanisms in obesity-associated metabolic disease

    Författare :Louise Olofsson; Göteborgs universitet; []
    Nyckelord :obesity; metabolic syndrome; cholesterol; resting metabolic rate; insulin resistance; serum amyloid A; S100 calcium binding protein A1; Zn-alpha2-glycoprotein; CCAAT enhancer binding protein alpha;

    Sammanfattning : Obesity is associated with increased morbidity and mortality. Subjects with obesity are at risk of developing several serious conditions such as type 2 diabetes, hypertension, coronary heart disease and stroke. LÄS MER