Sökning: "cholera vaccine"

Visar resultat 1 - 5 av 27 avhandlingar innehållade orden cholera vaccine.

1. 1. Development of novel vaccine strains of Vibrio cholerae and studies on the role of serotype in epidemic spread of cholera

   Författare :Stefan Karlsson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cholera; Vibrio cholerae; Serotype; Ogawa; Inaba; Hikojima; Vaccine; Immunogenicity; serotype switching; wbeT;

   Sammanfattning : Cholera, caused by bacterium Vibrio cholerae O1, is a severe diarrheal disease with an estimated 3-5 million cases and more than 140 000 deaths every year particularly affecting children under 5 years of age. It can be found all over the world and often causes cholera in places where access to clean water or proper sanitary facilities are limited or compromised. LÄS MER

3. 2. A mouse model for direct evaluation of cholera vaccines

   Författare :Erik Nygren; Göteborgs universitet; []
   Nyckelord :Vibrio cholerae; cholera vaccine; cholera toxin; LPS; anti-bacterial immunity; IgA; challenge; protection; colonization;

   Sammanfattning : Cholera continues to be an important cause of morbidity and mortality in large parts of the developing world and is a significant negative factor for economic development. Vibrio cholerae bacteria of the O1 or O139 serogroup can cause disease due to their ability to colonize the intestine and produce an enterotoxin, cholera toxin (CT). LÄS MER

4. 3. Heat shock proteins as vaccine adjuvants

   Författare :Khaleda Rahman Qazi; Carmen Fernández; Qijun Chen; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Heat shock protein; vaccine; adjuvant; BCG; Immunology; Immunologi;

   Sammanfattning : New efficient vaccines against infectious diseases are in demand. Some important factors impeding the vaccine development are the poor immunogenicity and the MHC restriction of the immune responses to a number of antigens. LÄS MER

5. 4. CTA1-DD; A novel vaccine adjuvant system based on ADP-ribosyltransferase activity and B cell targeting

   Författare :Lena Ågren; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cholera toxin; ADP-ribosyltransferase activity; adjuvant; vaccine; B cells; targeting;

   Sammanfattning : The ADP-ribosylating enterotoxins, cholera toxin (CT) and E. coli heat-labile toxin (LT) are among the most powerful immunogens and adjuvants yet described. An innate problem, though, is their strong toxic effects, largely due to their promiscuous binding to all nucleated cells via their B-subunits. LÄS MER

7. 5. Studies on the immuno-modulating properties of the cholera toxin A1-based fusion protein CTA1-DD

   Författare :Anna Eriksson; Göteborgs universitet; []
   Nyckelord :adjuvant; cholera toxin; mucosa; targeting; B cell; immuno-modulation; vaccine;

   Sammanfattning : The present work was aimed at exploring the immuno-modulating properties of the novel cholera toxin (CT)-based vaccine adjuvant CTA1-DD, which combines the full enzymatic activity of the A1 subunit of CT with B cell targeting. We have studied the efficacy of the CTA1-DD adjuvant to enhance immune responses in mice after nasal administration. LÄS MER