Sökning: "chlomethiazole"
Hittade 2 avhandlingar innehållade ordet chlomethiazole.
1. Molecular basis for the anti-inflammatory properties of chlomethiazole
Sammanfattning : Chlomethiazole (CMZ) exerts neuroprotective effects in animal models of stroke, and its clinical efficacy is currently evaluated in acute stroke patients. CMZ also protects the liver from alcohol- induced oxidative damage by inhibiting the cytochrome P450 2E1 (CYP2E1), as well as inflammation associated with alcohol liver disease (ALD) by inhibiting cytokine expression. LÄS MER
2. Genetic polymorphism and regulation of cytochrome P450 2E1
Sammanfattning : Cytochrome P450 2E1 (CYP2E1) participates in the metabolism of several xenobiotics. A physiological role of CYP2E1 is its ability to convert acetone into gluconeogenetic precursors. Due to a pronounced oxidase activity CYP2E1 can generate substantial amount of oxygen free radicals and may contribute to oxidative stress. LÄS MER