Sökning: "chemGPS-NP"
Hittade 4 avhandlingar innehållade ordet chemGPS-NP.
1. Studies on anti-leukemic terpenoids from medicinal mushrooms and marine sponges with ChemGPS-NP-based targets investigation of lead compounds
Sammanfattning : This thesis investigates the anti-leukemic activity of terpenoids isolated from medicinal mushrooms and marine sponges, as well as their possible targets and mechanisms of action.In the first section, we focused on studying the triterpenoidal components of three triterpenoid-enriched medicinal mushrooms Antrodia cinnamomea, Ganoderma lucidum, and Poria cocos, which have been used in folk medicine for centuries and also developed into several contemporary marketed products. LÄS MER
2. ChemGPS-NP and the Exploration of Biologically Relevant Chemical Space
Sammanfattning : Chemical space is basically infinite, and comprises all molecules that could possibly exist. Intelligent ways to efficiently navigate through chemical space and to select promising compounds in drug discovery are important tasks, and the focus of this thesis. In this work a new model for chemical space navigation, ChemGPS-NP, was developed. LÄS MER
3. Studies of Cytotoxic Compounds of Natural Origin and their Mechanisms of Action
Sammanfattning : Cancer incidence is increasing and novel anticancer drugs with new mechanisms of action are essential for future chemotherapeutic treatment. Natural products have historically played an important role in the development of anti-cancer drugs and have potential to do so also in the future. LÄS MER
4. Exploring evolutionary and chemical space using chemoinformatic tools and traditional methods in pharmacognosy
Sammanfattning : The number of new drugs coming to the market is declining while interest in lead discovery from natural resources is seeing a revival. Although methods for isolation and identification of natural products have advanced tremendously, methods for selection of potential leads have fallen behind. LÄS MER