Sökning: "chelation control"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden chelation control.

  1. 1. Heck Reactions with Aryl Chlorides : Studies of Regio- and Stereoselectivity

    Författare :Gopal K. Datta; Mats Larhed; Anders Hallberg; Martin Oestreich; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Heck reaction; aryl chloride; vinyl ether; regioselective; stereoselective; palladium; chelation control; microwave; Pharmaceutical chemistry; Farmaceutisk kemi;

    Sammanfattning : Homogeneous palladium-catalyzed Heck vinylation of aryl chlorides was investigated under air using Herrmann’s palladacycle and the P(t-Bu)3-liberating salt [(t-Bu)3PH]BF4. Based on the results, controlled microwave heating was utilized to accelerate model Heck reactions with aryl chlorides down to 30 min employing an electron-poor olefin and a mixture of an ionic liquid and 1,4-dioxane as solvent. LÄS MER

  2. 2. Fast Microwave-Enhanced Intra-, Pseudo-intra- and Intermolecular Heck Reactions

    Författare :Andreas Svennebring; Mats Larhed; Anja Sandström; Erik Van der Eycken; Uppsala universitet; []
    Nyckelord :Pharmaceutical chemistry; palladium; Heck reaction; chelation control; microwave; Farmaceutisk kemi;

    Sammanfattning : The Heck reaction is one of the most appreciated methods for carbon-carbon bond formation. Due to its mildness and ability to be tuned by additives, it often leaves few alternative competitive reactions. It has also proven easy to develop the reaction conditions in an environmentally benign direction. LÄS MER

  3. 3. Palladium-Catalysed Couplings in Organic Synthesis : Exploring Catalyst-Presenting Strategies and Medicinal Chemistry Applications

    Författare :Alejandro Trejos; Mats Larhed; Jianliang Xiao; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Mizoroki-Heck arylation; Suzuki coupling; domino reaction; stereoselective; palladium; chelation control; vinyl ether; HIV-protease inhibitors; HIV-integrase inhibitors; Kemi med inriktning mot organisk kemi; Chemistry with specialization in Organic Chemistry;

    Sammanfattning : Palladium-catalysed coupling reactions have been embraced by synthetic chemists as one of the preferred means for smooth formation of new carbon-carbon bonds: a truly ubiquitous methodology of synthesizing complex molecules.This thesis describes the study of a series of palladium(0)-catalysed C2-arylations of a 1-cyclopentenyl ether, equipped with a chiral (S)-N-methyl-pyrrolidine auxiliary. LÄS MER

  4. 4. Stereoselective Nucleophilic Additions to α-Amino Aldehydes: Application to Natural Product Synthesis

    Författare :Per Restorp; Peter Somfai; Timothy J. Donohoe; KTH; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Stereoselective synthesis; Substrate-control; α-Amino aldehydes; Mukaiyama aldol; Allylsilanes; [3 2]-Annulation; -Alexine; DGDP; Vinyl epoxides; Regioselectivity; Alkyne nucleophiles; Organic chemistry; Organisk kemi;

    Sammanfattning : This thesis deals with the development and application of new synthetic methodology for stereo- or regioselective construction of carbon-carbon bonds in organic synthesis. The first part of this thesis describes the development of a divergent protocol for stereoselective synthesis of chiral aminodiols by employing Mukaiyama aldol additions to syn- and anti-α-amino-β-silyloxy aldehydes. LÄS MER

  5. 5. Selectivity in Palladium- and Enzyme-Catalyzed Reactions : Focusing on Enhancement of Reactivity

    Författare :Peter Nilsson; Anders Hallberg; Mats Larhed; Matthias Beller; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Palladium; Heck; PCR; Microwaves; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi;

    Sammanfattning : Catalysis has a profound impact on all living species on the earth. Nature’s catalysts, the enzymes, have the ability to selectively promote a specific bio-chemical transformation, given the required substrate. LÄS MER