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  1. 1. On the way of making plants smell like moths - a synthetic biology approach

    Författare :Bao-Jian Ding; Funktionell zoologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; moth pheromone; transcriptome; fatty acyl desaturase; fatty acyl reductase; acetyltransferase; chain shortening; chain elongation; heterologous expression; synthetic biology; plant expression;

    Sammanfattning : Moth caterpillars are major agricultural pests in many parts of the world. In general female moths attract male mates with their pheromone over long distance. Most of the described moth pheromones belong to the same class of chemical compounds, fatty acid derivatives that are produced de novo in the pheromone gland. LÄS MER

  2. 2. Enzymes involved in heparan sulfate chain elongation : Function of a novel family of tumor suppressors?

    Författare :Thomas Lind; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; heparan sulfate; biosynthesis; glycosyltransferase; EXT1; EXT2; UDP-glucosedehydrogenase; KfiC; Biokemi; Biochemistry; Biokemi; Medical and Physiological Chemistry; medicinsk och fysiologisk kemi;

    Sammanfattning : Heparan sulfate (HS) is a glycosaminoglycan associated with many physiological functions such as regulation of growth factor action and cell adhesion. The HS polysaccharide is synthesized by alternating addition of D-glucuronic acid (GlcA) and N-acetyl-D-glucosamine (GlcNAc) units from the corresponding UDP-sugar precursors. LÄS MER

  3. 3. Metabolic Significance of Fatty Acid Elongation

    Författare :Damir Zadravec; Anders Jacobsson; Douglas Tocher; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology; Fysiologi; fysiologi; Physiology;

    Sammanfattning : Very long-chain fatty acids (VLCFAs), including polyunsaturated fatty acids (PUFAs), are essential lipids whose functional diversity is made possible by variation in their chain length and degree of unsaturation. Fatty acids can either be derived directly from the diet or they can be synthesized de novo through lipogenesis, up to 16 carbons in length by fatty acid synthase. LÄS MER

  4. 4. Characterizing Elongation of Protein Synthesis and Fusidic Acid Resistance in Bacteria

    Författare :Srihari Nagendra Ravi Kiran Koripella; Suparna Sanyal; Daniel Wilson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ribosome; Elongation factor-G; FusB; GTP; Staphylococcus aureus; Escherichia coli and Fusidic acid; Molecular Biology; Molekylärbiologi;

    Sammanfattning : Protein synthesis is a highly complex process executed by the ribosome in coordination with mRNA, tRNAs and translational protein factors. Several antibiotics are known to inhibit bacterial protein synthesis by either targeting the ribosome or the proteins factors involved in translation. LÄS MER

  5. 5. Elovl3 and very long chain fatty acids; role in metabolism

    Författare :Andreas Jakobsson; Anders Jacobsson; James Ntambi; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fatty acids metabolism elongation; Physiology; Fysiologi;

    Sammanfattning : Fatty acids (FA) are important in several aspects of cellular function, for example as structural molecules and metabolic substrates. The bulk of FA up to 16 carbons (palmitic acid) in length are synthesised by a cytosolic enzyme complex called fatty acid synthase (FAS), while FA can be further elongated into very long-chain fatty acids (VLCFA) by membrane-bound enzymes in the endoplasmatic reticulum (ER). LÄS MER