Sökning: "cerebral microdialysis"

Visar resultat 16 - 20 av 27 avhandlingar innehållade orden cerebral microdialysis.

1. 16. On severe traumatic brain injury : aspects of an intra cranial pressure-targeted therapy based on the Lund concept

   Författare :Magnus Olivecrona; Lars-Owe D Koskinen; Bertil Romner; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; severe traumatic brain injury; ICP targeted therapy; ICP; hemicraniectomy; seizures; prostacyclin; microdialysis; outcome; S100B; NSE; Neurosurgery; Neurokirurgi;

   Sammanfattning : Severe Traumatic Brain Injury (sTBI) is a major cause of mortality and morbidity. At the Department of Neurosurgery Umeå University Hospital subjects with sTBI are treated with an intracranial pressure (ICP) guided therapy based on physiological principles, aiming to optimise the microcirculation of the brain so avoiding secondary brain injuries. LÄS MER

3. 17. The Neurological Wake-up Test in Neurocritical Care

   Författare :Karin Skoglund; Niklas Marklund; Per Enblad; Tiit Mathiesen; Uppsala universitet; []
   Nyckelord :Intracranial pressure; Cerebral perfusion pressure; Propofol sedation; Wake-up test; stress hormones; intracerebral microdialysis; brain tissue oxygenation; jugular venous oxygenation; Neurokirurgi; Neurosurgery;

   Sammanfattning : The neurological wake-up test, NWT, is a clinical monitoring tool that can be used to evaluate the level of consciousness in patients with traumatic brain injury (TBI) and subarachnoid haemorrhage (SAH) during neurocritical care (NCC). Since patients with severe TBI or SAH are often treated with mechanical ventilation and sedation, the NWT requires that the continuous sedation is interrupted. LÄS MER

4. 18. Quality systems to avoid secondary brain injury in neurointensive care

   Författare :Lena Nyholm; Per Enblad; Camilla Fröjd; Anders Lewén; Bo-Michael Bellander; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Traumatic brain injury; Subarachnoid hemorrhage; Intracranial pressure; Quality register; Checklist; Nursing interventions; Pressure autoregulation; Intracranial compliance; Hyperthermia; Cerebral energy metabolism; Microdialysis and Brain tissue oxygenation.; Neurokirurgi; Neurosurgery;

   Sammanfattning : Outcome after traumatic brain injury (TBI) depends on the extent of primary cell death and on the development of secondary brain injury. The general aim of this thesis was to find strategies and quality systems to minimize the extent of secondary insults in neurointensive care (NIC). LÄS MER

5. 19. Studies on inflammation in the acute phase of aneurysmal Subarachnoid Hemorrhage

   Författare :Pavlos Vlachogiannis; Elisabeth Ronne-Engström; Lars Hillered; Johan Wikström; Bo-Michael Bellander; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; subarachnoid hemorrhage SAH ; inflammation; Delayed Cerebral Ischemia DCI cerebral vasospasm; Proximity Extension Assay PEA technology; Neurokirurgi; Neurosurgery;

   Sammanfattning : Spontaneous subarachnoid hemorrhage (SAH) accounts for 5% of all strokes and is associated with high morbidity and mortality. Rupture of intracranial aneurysm is the cause in 85% of cases. LÄS MER

7. 20. Modeling disturbances of cholinergic systems : possible relevance for schizophrenia

   Författare :Anna Mattsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Cholinergic; nucleus basalis; 192 IgG-saporin; schizophrenia; locomotor activity; dopamine; microdialysis; memory; MRI;

   Sammanfattning : Schizophrenia is a severe, chronic mental disorder. The etiology remains unknown but alterations in cholinergic neurotransmission is one, among other, disturbances in the brain that have been implicated in schizophrenia. LÄS MER