Sökning: "cerebral microdialysis"

Visar resultat 11 - 15 av 27 avhandlingar innehållade orden cerebral microdialysis.

1. 11. Aspects of Induced Hypothermia following Cardiopulmonary Resuscitation : Cerebral and Cardiovascular Effects

   Författare :Johanna Nordmark; Sten Rubertsson; Per Enblad; Jacob Johansson; Patrick Kochanek; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anaesthetics and intensive care; Anestesiologi och intensivvård;

   Sammanfattning : Hypothermia treatment with cooling to a body temperature of 32-34°C has been shown to be an effective way of improving neurological outcome and survival in unconscious patients successfully resuscitated after cardiac arrest (CA). The method is used clinically but there are still many questions on the biological mechanisms and on how the treatment is best performed. LÄS MER

3. 12. Cerebral Perfusion and Metabolism during Experimental Extracorporeal Circulation

   Författare :Ove Jonsson; Stefan Thelin; Fredrik Lennmyr; Sven-Erik Ricksten; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cerebral perfusion; Experimental brain research; Experimentell hjärnforskning; Thoraxkirurgi; Thorax Surgery;

   Sammanfattning : Neurologic injuries are major causes of mortality and morbidity after cardiac surgery. This thesis aimed to investigate cerebral metabolism and perfusion abnormalities in pigs during hypothermic circulatory arrest, selective antegrade cerebral perfusion (SACP) and extracorporeal circulation following progressive venous stasis. LÄS MER

4. 13. Metabolic and Endocrine Response in the Acute Stage of Subarachnoid Hemorrhage

   Författare :Christoffer Nyberg; Elisabeth Ronne Engström; Torbjörn Karlsson; Lars Hillered; Silvana Naredi; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Subarachnoid hemorrhage; Energy Expenditure; BNP; Animal Model; Cortisol; Microdialysis; Neurokirurgi; Neurosurgery;

   Sammanfattning : The rupture of an aneurysm in subarachnoid hemorrhage (SAH) is a dramatic event causing a severe impact on the brain and a transient or permanent ischemic condition. Several types of responses to meet the challenges of SAH have been found in the acute phase, including activation of the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system, elevated levels of brain natriuretic peptide (BNP), and disturbances in cerebral and systemic metabolism. LÄS MER

5. 14. Monitoring of extracellular substances after spontaneous and experimental subarachnoid hemorrhage

   Författare :Magnus Runnerstam; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Subarachnoid hemorrhage; Microdialysis; Amino acids; GFAP; Iron; Apoptosis;

   Sammanfattning : Even though survival is considerably enhanced after surgical treatment of an aneurysmal subarachnoid hemorrhage (SAH), there is a critical period, which keeps the patient in intensive care for days or even weeks. Complications, such as vasospasm, ischemia and brain edema ultimately lead to further brain damage. LÄS MER

7. 15. The role of reactive oxygen species in traumatic brain injury : Experimental studies in the rat

   Författare :Niklas Marklund; Uppsala universitet; []
   Nyckelord :Medical sciences; Apoptosis; CBF; controlled cortical contusion injury; 3; 4-dihydroxybenzoate; fluid percussion injury; glucose; 4-hydroxybenzoate; microdialysis; Morris Water Maze; neuroprotection; nitrones; PBN; rat; reactive oxygen species ROS ; salicylate; S-PBN; TBI; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Neurosurgery; neurokirurgi;

   Sammanfattning : Traumatic brain injury (TBI) is a major cause of mortality and disability. As common sequelae in survivors of TBI are disabling functional, emotional and cognitive disturbances, improved treatment of TBI patients is urgently needed. At present, no neuroprotective pharmacological treatment exists. LÄS MER