Sökning: "cerebral glucose metabolism"

Visar resultat 1 - 5 av 28 avhandlingar innehållade orden cerebral glucose metabolism.

  1. 1. Astrocyte metabolism following focal cerebral ischemia

    Författare :Anna E Thoren; Göteborgs universitet; []
    Nyckelord :Astrocyte; metabolism; focal cerebral ischemia; reperfusion; infarct; [1-14C]acetate; [U-14C]glucose; glutamine; glutamate; ATP; ADP; lactate; MCT4; immunogold cytochemistry;

    Sammanfattning : Stroke is one of the leading causes of disability and death. Most often, stroke results from blockage of an artery in the brain leading to tissue infarction within the perfusion territory of the affected vessel. LÄS MER

  3. 2. Bedside monitoring of cerebral energy metabolism using intracerebral microdialysis during neuro intensive care

    Författare :Nils Ståhl; Neurokirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsykologi; neurofysiologi; Neurologi; neuropsychology; Neurology; glycerol.; glutamate; pyruvate; lactate; glucose; hyperglycaemia; intensive care; brain injury; Human; cerebral microdialysis; neurophysiology;

    Sammanfattning : In clinical situations with raised intracranial pressure (ICP) and impending insufficient cerebral blood flow (ischaemia), bedside information about energy metabolism in the brain would be helpful. Microdialysis is a technique that makes it possible to monitor the interstitial concentrations of various compounds in an organ. LÄS MER

  4. 3. Mathematical Modelling of Cerebral Metabolism : From Ion Channels to Metabolic Fluxes

    Författare :Nicolas Sundqvist; Gunnar Cedersund; Maria Engström; Roland Nilsson; Sebastian Sten; João Duarte; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The brain is the most metabolically active organ in the human body and therefore rely on a continuous supply of oxygen and glucose. Neuronal stimulation in specific regions of the leads to the firing of action potentials, a process facilitated by voltage-gated ion channels in the neurons’ cell membranes. LÄS MER

  5. 4. Links between plasma apoE and glucose metabolism, brain insulin signaling, and synaptic integrity : Relevance to Alzheimer’s disease pathophysiology

    Författare :Anna Edlund; Henrietta Nielsen; William Rebeck; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; apolipoprotein E; insulin; metabolism; Amyloid precursor protein APP ; Fe65; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Human apolipoprotein E (apoE) exists as three main isoforms called apoE2, apoE3, and apoE4, of which the E4 isoform is associated with increased Alzheimer’s disease (AD) risk. Brain glucose hypometabolism, linked to synaptic dysfunction, occurs years before symptom onset in AD, especially in APOEε4-carriers. LÄS MER

  7. 5. Severe cerebral emergency : aspects of treatment and outcome in the intensive care patient

    Författare :Marie Rodling Wahlström; Silvana Naredi; Sven-Erik Gisvold; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; severe traumatic brain injury; intracranial pressure-targeted therapy; albumin; prostacyclin; endothelial dysfunction; pro-inflammatory cytokines; subarachnoid haemorrhage; asymmetric dimethylarginine; Anaesthetics and intensive care; Anestesiologi och intensivvård; Anaesthesiology; anestesiologi;

    Sammanfattning : Severe Traumatic Brain Injury (TBI) and aneurysmal Subarachnoid Hemorrhage (SAH) are severe cerebral emergencies. They are common reasons for extensive morbidity and mortality in young people and adults in the western world. LÄS MER