Sökning: "ceramide"

Visar resultat 16 - 20 av 36 avhandlingar innehållade ordet ceramide.

  1. 16. Adipose tissue inflammation, hepatic fat accumulation and insulin resistance

    Författare :Maria Kolak; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Insulin resistance is the central feature of a variety of metabolic disorders, such as type 2 diabetes and the metabolic syndrome. The incidence of these disorders, often together with obesity, is currently increasing throughout the world. LÄS MER

  3. 17. Regulation of p53 and susceptibility to cell death in chemically-induced preneoplastic hepatocytes

    Författare :Ilona Silins; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Induction of preneoplastic lesions, termed enzyme-altered foci (EAF), is considered to be an early step in the development of liver cancer. In view of the relatively homogenous properties of the majority of EAF, these lesions are suggested to arise as an adaptive response to toxic stress. LÄS MER

  4. 18. Molecular organization and in situ assembly of the human skin barrier

    Författare :Lianne den Hollander; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : A deficient skin barrier function is a characteristic feature of skin diseases such as eczema, psoriasis and the ichtyoses. A malformation of the lipid matrix might be a major factor in barrier deficient skin disease. LÄS MER

  5. 19. Studies of sulfatide expression in relation to beta cell function

    Författare :Maria K. Blomqvist; Göteborgs universitet; []
    Nyckelord :sulfatide; glycosphingolipid; insulin; beta cell; diabetes mellitus; animal models; ; beta cell line;

    Sammanfattning : Previous studies have shown that the glycosphingolipid sulfatide (3´-sulfogalactosyl-ceramide) is present and functionally involved in pancreatic beta cells. In these cells, sulfatide is synthesised as two major isoforms, C16:0 and C24:0 sulfatide, with different length of the fatty acid chain of the ceramide moiety. LÄS MER

  7. 20. Computational modeling of biological barriers

    Författare :Christian Wennberg; Erik Lindahl; Thomas Cheatham; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular dynamics; cholesterol; lipid bilayer; permeability; long-range interactions; Lennard-Jones; dispersion; particle-mesh Ewald; stratum corneum; skin formation; Biological Physics; Biologisk fysik;

    Sammanfattning : One of the most important aspects for all life on this planet is the act to keep their biological processes in a state where they do not reach equilibrium. One part in the upholding of this imbalanced state is the barrier between the cells and their surroundings, created by the cell membrane. LÄS MER