Sökning: "central hyperexcitability"
Visar resultat 1 - 5 av 10 avhandlingar innehållade orden central hyperexcitability.
1. Mechanisms of excitability in the central and peripheral nervous systems : Implications for epilepsy and chronic pain
Sammanfattning : The work in this thesis concerns mechanisms of excitability of neurons. Specifically, it deals with how neurons respond to input, and how their response is controlled by ion channels and other active components of the neuron. LÄS MER
2. Experimental Aspects on Chronic Whiplash-Associated Pain
Sammanfattning : Introduction: Chronic pain after whiplash trauma (chronic WAD) to the neck is still a common clinical problem in terms of pain management, rehabilitation and insurance claims. In contrast to the increased knowledge concerning mechanisms of chronic pain in general, no clinical guidelines exist concerning assessment, pain control and rehabilitation of patients with chronic WAD. LÄS MER
3. Comprehensive evaluation of spasticity and other sensorimotor dysfunctions after lesions to the central or peripheral nervous system
Sammanfattning : Background: Understanding how sensorimotor impairments may contribute to changes in body structure and function, and also to activity and participation limitations is an important challenge in neurorehabilitation research, of high clinical relevance. Available assessment methods include mainly clinical scales, often with inadequate psychometric properties, such as the Modified Ashworth scale for assessment of spasticity. LÄS MER
4. Experimental and clinical studies on adenosine receptor stimulation in cutaneous hypersensitivity and neuropathic pain
Sammanfattning : The endogenous compound adenosine (ADO) has a wide range of physiological effects. Numerous animal studies and a limited number of human studies have shown antinociceptive effects of ADO and its analogues. The spinal cord dorsal column, where ADO receptors are found in high numbers, is a major site of action for this effect. LÄS MER
5. Pain influences somatosensory perception : an experimental and clinical study
Sammanfattning : The underlying mechanisms maintaining long-term pain localised to musculoskeletal structures and joints are not infrequently unknown. In routine clinical work with such patients insufficient attention has been paid to phenomena indicating altered excitability of the central nervous system (CNS). LÄS MER