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1. 1. Exploring Cellular Dynamics : From Vesicle Tethering to Cell Migration

   Författare :Parham Ashrafzadeh; Johan Kreuger; Jonas Fuxe; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; angiogenesis; cancer; cell migration; exocyst complex; exocytosis; FGD5; lipid rafts; plasma membrane; receptor trafficking; VEGFR2;

   Sammanfattning : Cells in the body communicate with each other in order to cooperate efficiently. This communication is in part achieved by regulated secretion of signaling molecules, which when released from a cell may activate receptors present at the plasma membrane of an adjacent cell. Such signals affect both cell fate and behavior. LÄS MER

3. 2. Cellular receptors for species B adenoviruses

   Författare :Marko Marttila; Niklas Arnberg; Göran Wadell; Tomas Bergström; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adenovirus; CD46; CD80; CD86; Species B; Receptor; Internalization; Infection; Tropism; Virology; Virologi;

   Sammanfattning : Adenoviruses belong to the most common human pathogens. The severity of infection varies greatly, from subclinical to lethal, depending on the virus type and immune status of the infected host. The 51 known human adenovirus serotypes are divided into six species (A-F) based on characteristics such as tropism. LÄS MER

4. 3. Spinal Acetylcholine Release : Mechanisms and Receptor Involvement

   Författare :Mahinda Kommalage; Urban Höglund; Ernst Brodin; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; acetylcholine release; spinal antinociception; nicotinic receptor; serotonin; GABA; Neurovetenskap; Neurology; Neurologi;

   Sammanfattning : Impulses coming from peripheries are modified in the spinal cord and transmitted to the brain. Several neurotransmitters have been involved in the processing of impulses in the spinal dorsal horn. Acetylcholine (ACh) is one of many neurotransmitters involved in the regulation of nociception in the spinal cord. LÄS MER

5. 4. Studies of the Neuropeptide Y Receptor Y2 in Human and Zebrafish

   Författare :Helena Fällmar; Dan Larhammar; Ingrid Lundell; Nina Mohell; Raquel E. Rodríguez Rodríguez; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Y2-receptor; NPY; PYY; G-protein-coupled receptor; mutagenesis; receptor binding; zebrafish; evolution; Pharmacology; Farmakologi; Farmakologi; Pharmacology;

   Sammanfattning : The G-protein coupled receptors (GPCRs) comprise the largest family of receptors in humans and other vertebrates. They are embedded in the cell membrane and are activated by many different signaling molecules. Activation modulates cellular signal transduction pathways and influences many physiological processes. LÄS MER

7. 5. Erythropoietin receptor in growth control and anti-estrogen resistance of estrogen receptor positive breast cancer

   Författare :Susann Reinbothe; Avdelningen för translationell cancerforskning; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tamoxifen resistance; proliferation; PI3k pathway; Breast cancer; erythropoietin receptor; estrogen receptor;

   Sammanfattning : The main function of Erythropoietin (EPO) and its receptor (EPOR) is the stimulation of erythropoiesis. Therefore, recombinant human EPO (rhEPO) is used to treat anemia in cancer patients, but some studies have reported that rhEPO treatment might promote tumor progression. Additionally, EPOR expression has been detected in various cancer forms. LÄS MER