Sökning: "cellular origin"

Visar resultat 1 - 5 av 193 avhandlingar innehållade orden cellular origin.

1. 1. Cellular Origin and Development of Glioma

   Författare :Nanna Lindberg; Lene Uhrbom; Bengt Westermark; Kristian Pietras; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioma; brain tumor; PDGF; RCAS TV-A; cell of origin; glial cell; oligodendrocyte progenitor cell; DNA repair; homology-directed repair; RAD51; angiogenesis; histidine-rich glycoprotein; Morphology; cell biology; pathology; Morfologi; cellbiologi; patologi; Molecular Medicine; molekylär medicin genetik och patologi ;

   Sammanfattning : Gliomas are the most common primary tumors of the central nervous system believed to arise from glial cells. Invasive growth and inherent propensity for malignant progression make gliomas incurable despite extensive treatment. LÄS MER

3. 2. Immunoglobulin Gene Analysis in Different B cell Lymphomas : With Focus on Cellular Origin and Antigen Selection

   Författare :Mia Thorsélius; Richard Rosenquist Brandell; Christer Sundström; Anders Rosén; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; B cell lymphoma; Immunoglobulin; V gene; somatic hypermutation; antigen selection; quantitative PCR; Genetik; Clinical genetics; Klinisk genetik;

   Sammanfattning : B cell lymphoma (BCL) comprises a biologically and clinically heterogeneous group of tumors deriving from different stages of B cell development. The immunoglobulin (Ig) variable heavy chain (VH) gene rearrangement is unique for each BCL and can be used to reveal cellular origin, to study signs of antigen selection and to quantify tumor cell load. LÄS MER

4. 3. Analysis of Immunoglobulin Genes and Telomeres in B cell Lymphomas and Leukemias

   Författare :Sarah Walsh; Richard Rosenquist; Christer Sundström; Anna Laurell; Andreas Rosenwald; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; B cell lymphoma leukemia; mantle cell lymphoma; hairy cell leukemia; lymphoplasmacytic lymphoma; immunoglobulin genes; antigen selection; telomeres; cellular origin; somatic hypermutation; Genetik; Clinical genetics; Klinisk genetik;

   Sammanfattning : B cell lymphomas and leukemias are heterogeneous tumors with different cellular origins. Analysis of immunoglobulin (Ig) genes enables insight into the B cell progenitor, as Ig somatic hypermutation correlates with antigen-related B cell transit through the germinal center (GC). LÄS MER

5. 4. The cell cycle of the hyperthermophilic archaeal genus Sulfolobus

   Författare :Karin Hjort; Patrick Dennis; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microbiology; Cell cycle; Sulfolobus; Archaea; Origin; Replication; SIRV2; Mikrobiologi; Microbiology; immunology; infectious diseases; Mikrobiologi; immunologi; infektionssjukdomar; mikrobiologi; Microbiology;

   Sammanfattning : The third domain of life, Archaea is one of the three main evolutionary lineages together with the Bacteria and the Eukarya domains. The archaea are, despite their prokaryotic cell organisation, more closely related to eukaryotes than to bacteria in terms of the informational pathways (DNA replication, transcription and translation). LÄS MER

7. 5. Interplay Between Cell of Origin and Oncogenic Activation in Glioma

   Författare :Yiwen Jiang; Lene Uhrbom; Anders Persson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioma; PDGF; cell of origin; Sox5; glioma initiating cells; Oncology; Onkologi;

   Sammanfattning : Glioma is the most frequent primary tumor of the central nervous system. By using the RCAS/tv-a mouse glioma model, we have studied mechanisms controlling glioma development and the effect of cell of origin on these processes.SOX5 was identified as a brain tumor locus in a retroviral insertional mutagenesis screen of PDGF-B induced mouse gliomas. LÄS MER